Search for dissertations about: "histone deacetylase inhibitors"

Showing result 1 - 5 of 13 swedish dissertations containing the words histone deacetylase inhibitors.

  1. 1. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Limin Ma; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE

  2. 2. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Author : Steven Gray; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Abstract : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. READ MORE

  3. 3. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells

    University dissertation from Linköping University Electronic Press

    Author : Veronika Viktorija Borutinskaite; Karl Eric Magnusson; Ruta Navakauskiene; Tor Olofsson; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; leukemia; histone deacetylase inhibitors; retinoic acid; differentiation; apoptosis; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi;

    Abstract : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. READ MORE

  4. 4. Pharmacological stimulation of endothelial function and long-term impact of hypertension in man

    University dissertation from Linköping University Electronic Press

    Author : Ott Saluveer; Göteborgs universitet.; Gothenburg University.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; t-PA; hypertension; fibrinolysis; endothelial function; valproic acid; histone deacetylase inhibitor; atorvastatin;

    Abstract : Background: Ischemic heart disease is a major cause of death globally. Rupture of a coronary atherosclerotic plaque with occluding thrombus formation is the main cause of myocardial ischemia and infarction. READ MORE

  5. 5. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials

    University dissertation from Göteborgs universitet

    Author : Henrik Jespersen; Göteborgs universitet.; Gothenburg University.; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic melanoma; Uveal melanoma; Humanized mouse models; Immunotherapy; Chimeric antigen receptor T cells; PD-1 inhibition; Epigenetics; Histone deacetylase inhibition;

    Abstract : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. READ MORE