Search for dissertations about: "histone deacetylase inhibitors"
Showing result 1 - 5 of 14 swedish dissertations containing the words histone deacetylase inhibitors.
-
1. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma
Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE
-
2. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors
Abstract : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. READ MORE
-
3. Characterization of proteins involved in differentiation and apoptosis of human leukemia and epithelial cancer cells
Abstract : Today, cancer is understood as an epigenetic as well as a genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. The latter changes may be an optimal target for novel anticancer agents. READ MORE
-
4. Pharmacological stimulation of endothelial function and long-term impact of hypertension in man
Abstract : Background: Ischemic heart disease is a major cause of death globally. Rupture of a coronary atherosclerotic plaque with occluding thrombus formation is the main cause of myocardial ischemia and infarction. READ MORE
-
5. Translational studies of metastatic melanoma in the era of immunotherapy - from humanized mouse models to clinical trials
Abstract : Immunotherapy with PD-1 inhibitors has transformed the treatment of met-astatic cutaneous mela- noma, and can lead to complete and durable responses in a proportion of patients. However, in around half of the patients, the treatment has little or no effect. READ MORE