Search for dissertations about: "hiv-1 reverse transcriptase"

Showing result 11 - 15 of 49 swedish dissertations containing the words hiv-1 reverse transcriptase.

  2. 11. Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

    Author : Johan Wannberg; Anders Hallberg; David C. Rees; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV; protease inhibitors; palladium; carbonylations; molybdenum hexacarbonyl; dihydropyrimidone; DHPM; microwave; cross-coupling; diazylhydrazines; carbon monoxide; synthesis; C2-symmetric; HIV-1 protease inhibitors; aminocarbonylation; fluorous; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. READ MORE

  4. 12. Factors influencing the evolution of HIV-1

    Author : Markus Birk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV; antiretroviral treatment; evolution; gag; pol; env;

    Abstract : Due to the high replication rate and the low fidelity of the viral reverse transcriptase (RT), various mutations are introduced continuously into the gene pool of HIV-1. Together with recombination events this leads to the evolution of countless quasispecies. READ MORE

  5. 13. Computational Studies of HIV-1 Protease Inhibitors

    Author : Wesley Schaal; Garland Marshall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV Protease; 3D-QSAR; CoMFA; Molecular Modelling; Force Field Parameterization; Quantum Mechanics; DFT; Enzyme Kinetics; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Abstract : Human Immunodeficiency Virus (HIV) is the causative agent of the pandemic disease Acquired Immune Deficiency Syndrome (AIDS). HIV acts to disrupt the immune system which makes the body susceptible to opportunistic infections. Untreated, AIDS is generally fatal. READ MORE

  6. 14. Virologic failure and HIV-1 drug resistance among antiretroviral therapy recipients in an urban resource-limited setting : the South African virologic evaluation (SAVE) study

    Author : Ziad El-Khatib; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1;

    Abstract : In sub-Saharan Africa, more than four million HIV-infected people have been initiated on antiretroviral therapy (ART); most only have access to first line-treatment, and few ART clinics can provide second- line regimens to everyone in need due to the cost of equipment to detect virologic failure and the cost of alternative drugs. Hence, sustaining the usage of first-line regimens is crucial. READ MORE

  7. 15. The effect of alpha-HGA on HIV-1 replication

    Author : Masoud Youssefi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; p24; capsid formation; alpha-HGA; antiretroviral; uptake;

    Abstract : Different classes of anti HIV-1 drugs are now available for treatment of HIV-1 infection. Although improved, these drugs show adverse effects and their long-term efficiency is severely hampered by the emergence of resistant viruses. Therefore, less toxic and more effective anti HIV-1 therapeutics agents are still needed. READ MORE