Search for dissertations about: "hlh"

Showing result 1 - 5 of 21 swedish dissertations containing the word hlh.

  2. 1. Functional collaboration between HLH transcription factors in B cell development

    Author : Ramiro Gisler; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; E47; Early B cell Factor EBF ; Clinical genetics; Klinisk genetik; HLH proteins; transcription factors; gene expression; B cell development; transcription regulation;

    Abstract : The cells in B cell development can be divided into several subgroups or fractions, e.g. early-pro-B-, pro-B, large-pre-B-, small-pre-B-, immature and mature B cells, where the stages reflect the maturity degree of the cells. READ MORE

  4. 2. Hemophagocytic lymphohistiocytosis and associations with malignancies

    Author : Alexandra Haara Löfstedt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In immune homeostasis, natural killer cells and cytotoxic T cells are responsible for clearance of virus-infected and tumor transformed cells, but also for turning off the immune response. Patients with familial hemophagocytic lymphohistiocytosis (HLH) have impaired cytotoxic function due to genetic aberrations in genes in the perforindependent cytotoxic pathway. READ MORE

  5. 3. Hyperinflammation in critically ill

    Author : Tatiana von Bahr Greenwood; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: A wide spectrum of inflammatory responses, with overlapping characteristics, is encountered in critically ill patients in intensive care. At one extreme, critically ill patients may develop the potentially fatal condition secondary hemophagocytic lymphohistiocytosis (sHLH), characterized by excessive inflammation (hyperinflammation), driven by a ‘cytokine storm’, and multiple organ failure. READ MORE

  6. 4. Clinical studies of hemophagocytic lymphohistiocytosis

    Author : Helena Trottestam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background and aims: The term hemophagocytic lymphohistiocytosis (HLH) comprises two main disease entities: the primary, familial form (FHL) and an acquired, secondary form (sHLH). FHL is autosomal recessive in inheritance, typically affects very young children and is almost invariably fatal unless treated. READ MORE

  7. 5. Genetic, cellular and clinical studies of hemophagocytic lymphohistiocytosis

    Author : Marie Meeths; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hemophagocytic lymphohistocytosis (HLH) is a life-threatening hyperinflammatory condition characterized by fever, cytopenia, hepatosplenomegaly, and sometimes hemophagocytosis. HLH is typically divided into two distinct groups, primary HLH and secondary HLH. READ MORE