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Showing result 1 - 5 of 43 swedish dissertations matching the above criteria.

  2. 1. Homocysteine in cardiovascular disease with special reference to longitudinal changes

    Author : Johan Hultdin; Torbjörn Nilsson; Bertil Kågedal; Umeå universitet; []
    Keywords : Medical sciences; homocysteine; methylenetetrahydrofolate reductase MTHFR ; first-ever stroke; first-ever myocardial infarction; longitudinal; prospective; risk factor; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

    Abstract : Abnormalities in homocysteine metabolism have been suggested as risk factors for stroke and myocardial infarction. In retrospective studies, elevated levels of total plasma homocysteine (tHcy) and/or methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism have indicated an increase in risk. READ MORE

  4. 2. Homocysteine and vascular morbidity and dementia in women. A prospective population study

    Author : Dimitri Zylberstein; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Women; population study; dementia; Homocysteine; MTHFR; myocardial infarctions; lacunar infarcts; epidemiology;

    Abstract : Homocysteine and cardiovascular morbidity and dementia in women - A prospective population study Dimitri Edin Zylberstein Institute of Medicine, The Sahlgrenska Academy, Department of Public Health and Community Medicine, Section of Primary Health Care, University of Gothenburg Abstract Purpose. The purpose of this thesis was to study cardiovascular morbidity and dementia in relation to homocysteine levels in women in a longitudinal, prospective population study over several decades. READ MORE

  5. 3. Homocysteine and Coronary Artery Disease With special Reference to Biochemical Effects Of Vitamin Therapy

    Author : Torfi Jonasson; Kardiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; pyridoxine.; oxidative stress; lipid peroxidation; inflammation; homocysteine; endothelial function; folate; F2-isoprostanes; cystatine C; Acut coronary syndrome; cardiovascular disease; asymmetric dimethylarginine; cobalamine;

    Abstract : An elevated plasma level of homocysteine has been suggested as a risk factor for cardiovascular disease. The objectives of this thesis were to study the influence of renal function on homocysteine levels in patients with coronary artery disease and to explore the association of elevated plasma levels of homocysteine to oxidative stress, inflammation, and endothelial dysfunction. READ MORE

  6. 4. Homocysteine and its determinants in relation to cardiovascular risk factors and myocardial infarction

    Author : Elisabet Söderström; Johan Hultdin; Torbjörn K. Nilsson; Anders Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homocysteine; folate; myocardial infarction; apolipoprotein; risk factors; cotinine; nicotine; tobacco; CTH; MTHFR; renal insufficiency; glomerular filtration rate; creatinine; cystatin C; shrunken pore syndrome; epidemiology; Clinical Chemistry; klinisk kemi;

    Abstract : Background: Globally, cardiovascular diseases (CVD), including myocardial infarction (MI) and stroke, are the leading cause of illness and death and constitute a significant part of the disease burden in Sweden and Western Europe. Age, hypertension, smoking, obesity, dyslipoproteinemia, diabetes, and impaired renal function are considered established risk factors for CVD. READ MORE

  7. 5. Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations

    Author : Anna Böttiger; Torbjörn Nilsson; Henrik Zetterberg; Örebro universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Folate receptor-alpha; Folate; FOLR1; Haplotypes; Homocysteine; Methylenetetrahydrofolate reductase; MTHFR; Polymorphisms; Pyrosequencing®; SSCP; Medicine; Medicin; Biomedicin; Biomedicine;

    Abstract : Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and neurocognitive disease such as dementia. The B vitamins folate and B12 are the main de terminants of tHcy. tHcy concentration can also be affected by mutations in genes coding for receptors, enzymes and transporters important in the metabolism of Hcy. READ MORE