Search for dissertations about: "homologous recombination"
Showing result 21 - 25 of 90 swedish dissertations containing the words homologous recombination.
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21. Cancer stem cells and homologous recombination deficiency in serous ovarian and endometrial carcinoma
Abstract : .... READ MORE
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22. Site-specific recombination in P2-like coliphages
Abstract : The scope of these studies has been to investigate the site-specific recombination systems of P2-like coliphages, both in an evolutionary perspective by a comparative analysis of related phages as well as in a functional perspective. Surveys of P2-like phages in Escherichia coli isolated from nature reveal the existence of seven discrete immunity classes and three integration sites, one of them previously unknown. READ MORE
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23. Molecular investigation of mucopolysaccharidosis type II (Hunter syndrome) in man
Abstract : Mucopolysaccharidosis type II or Hunter syndrome is a rare lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2-sulfatase (IDS). The disorder is inherited in an X-linked recessive fashion and has a broad spectrum of clinical phenotypes ranging from severe to mild. READ MORE
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24. Genomic rearrangements at the cause of three genetic disorders in man
Abstract : Genomic rearrangements are a common cause of genetic disorders in man. This thesis describes the analysis of genomic rearrangements observed in patients with the Hunter syndrome (MPS II), incontinentia pigmenti (IP) and the Blepharophimosis, ptosis and epicanthus inversus syndrome (BPES). MPS II is an X-linked recessive lysosomal storage disorder. READ MORE
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25. Silencing and DNA double-strand break repair in budding yeast
Abstract : Transcriptional silencing that makes large chromosomal domains inaccessible for the transcriptional apparatus is nucleated at DNA elements called silencers. In K.lactis a 102bp HMLα silencer was defined revealing three distinct protein-binding regions (A, B, and C) that were required for silencing of HMLα. READ MORE