Search for dissertations about: "homologous repair"

Showing result 1 - 5 of 62 swedish dissertations containing the words homologous repair.

2. 1. Bacterial DNA repair and molecular search

   Author : Arvid H. Gynnå; Johan Elf; Stephen Kowalczykowski; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA repair; DNA damage; homologous recombination; homologous repair; recombination; RecA; I-SceI; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : Surveillance and repair of DNA damage is necessary in all kinds of life. Different types of DNA damage require different repair mechanisms, but these mechanisms are often similar in all domains of life. The most serious type of damage, double stranded DNA breaks, are for example repaired in conceptually similar ways in both bacteria and eukaryotes. READ MORE

4. 2. Interstrand Crosslinks - Induction and repair

   Author : Daniel Vare; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Marcel Tijsterman; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ICL; DNA repair; interstrand crosslink; psoralen; molekylärgenetik; Molecular Genetics;

   Abstract : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. READ MORE

5. 3. Induction and repair of clustered DNA damage sites after exposure to ionizing radiation

   Author : Andris Abramenkovs; Bo Stenerlöw; Peter O'Neill; Uppsala universitet; []
   Keywords : NHEJ; DSB repair; clustered DNA damage; DNA repair; DNA-PKcs; HSCS; Ra-223; ionizing radiation; Medicinsk vetenskap; Medical Science;

   Abstract : The mechanisms that maintain genomic stability safeguard cells from constant DNA damage produced by endogenous and external stressors. Therefore, this thesis aimed to specifically address questions regarding the requirement and involvement of DNA repair proteins in the repair of various types of radiation-induced DNA damage. READ MORE

6. 4. Radiation response in human cells : DNA damage formation, repair and signaling

   Author : Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Abstract : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. READ MORE

7. 5. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks

   Author : Karin Karlsson; Bo Stenerlöw; Jörgen Carlsson; Thomas Helleday; Uppsala universitet; []
   Keywords : Molecular biology; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionising radiation; high-LET; heat-labile sites; PFGE; Molekylärbiologi;

   Abstract : Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual cells and organisms. Defects in the DNA repair may lead to cell death or genomic instability and development of cancer. READ MORE