Search for dissertations about: "homology recognition"

Showing result 1 - 5 of 25 swedish dissertations containing the words homology recognition.

  2. 1. Function via structure in vivo and in modeling

    Author : Johan Unge; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; medical informatics; Bioinformatics; L1.; protein synthesis; L22; crýstallography; structure core database; threading; Structural bioinformatics; homology recognition; biomatematik; medicinsk informatik; biomathematics biometrics; Bioinformatik;

    Abstract : Knowledge of biomolecules three-dimensional structure has provided a detailed understanding of their function. In recent years the number of new protein sequences has far exceeded the number of protein experimental structure determinations. READ MORE

  4. 2. The use of evolutionary information in protein alignments and homology identification

    Author : Tomas Ohlson; Arne Elofsson; Sven Hovmöller; Geoffrey J. Barton; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein alignment homology sequence profile; Theoretical chemistry; Teoretisk kemi;

    Abstract : For the vast majority of proteins no experimental information about the three-dimensional structure is known, but only its sequence. Therefore, the easiest way to obtain some understanding of the structure and function of these proteins is by relating them to well studied proteins. This can be done by searching for homologous proteins. READ MORE

  5. 3. Functional analysis of ligand recognition by the glucocorticoid receptor

    Author : Ulrika Lind; Karolinska Institutet; Karolinska Institutet; []
    Keywords : glucocorticoid receptor; steroid-binding; site-directed mutagenesis; protein-ligand interaction; mechanism of glucocorticoid action;

    Abstract : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor that belongs to the superfamily of nuclear hormone receptors. It contains three structural and functional domains. READ MORE

  6. 4. Molecular basis for enhanced T-cell recognition and cross-reactivity

    Author : Eva Allerbring; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with peptide/MHC complexes occur throughout the lifespan of T cells, from development to activation, with the origin of the peptide varying between self and foreign. READ MORE

  7. 5. Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands : Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

    Author : Christian Sköld; Anders Karlén; Anders Hallberg; Torbjörn Lundstedt; Tommy Liljefors; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; Angiotensin II; AT1; AT2; SAR; bioactive conformation; turn mimetic; peptidomimetic; DISCO; homology model; 3D-QSAR; CoMFA; Farmaceutisk kemi;

    Abstract : Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). READ MORE