Search for dissertations about: "homology"

Showing result 21 - 25 of 327 swedish dissertations containing the word homology.

  2. 21. Function via structure in vivo and in modeling

    Author : Johan Unge; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; medical informatics; Bioinformatics; L1.; protein synthesis; L22; crýstallography; structure core database; threading; Structural bioinformatics; homology recognition; biomatematik; medicinsk informatik; biomathematics biometrics; Bioinformatik;

    Abstract : Knowledge of biomolecules three-dimensional structure has provided a detailed understanding of their function. In recent years the number of new protein sequences has far exceeded the number of protein experimental structure determinations. READ MORE

  4. 22. Simplicial Complexes of Graphs

    Author : Jakob Jonsson; Anders Björner; John Shareshian; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Algebra and geometry; simplicial complex; monotone graph property; discrete Morse theory; simplicial homology; homotopy type; connectivity degree; Cohen-Macaulay complex; Euler characteristic; decision tree; Algebra och geometri; Algebra and geometry; Algebra och geometri;

    Abstract : Let G be a finite graph with vertex set V and edge set E. A graph complex on G is an abstract simplicial complex consisting of subsets of E. In particular, we may interpret such a complex as a family of subgraphs of G. READ MORE

  5. 23. Towards Mosquitocides for Prevention of Vector-Borne Infectious Diseases : discovery and Development of Acetylcholinesterase 1 Inhibitors

    Author : Sofie Knutsson; Anna Linusson; Fredrik Almqvist; Andreas Larsson; Ulf Nilsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mosquito; vector-borne diseases; vector control; insecticide; acetylcholinesterase; medicinal chemistry; high-throughput screening; organic synthesis; homology modeling; structure activity relationship; structure selectivity relationship; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Abstract : Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public health, with young children being among the worst affected. These diseases are transmitted by mosquitoes, also called disease vectors, which are able to transmit both parasitic and viral infections. READ MORE

  6. 24. Computational prediction of ligand binding in peptide G-protein coupled receptors

    Author : Silvana Vasile; Hugo Gutiérrez-de-Terán; Johan Åqvist; Herman Van Vlijmen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; GPCR; neuropeptide Y; angiotensin II receptor; molecular dynamics; free energy perturbation; homology modelling; computer simulations; peptide binding; peptidomimetics; binding free energy.;

    Abstract : G-protein coupled receptors (GPCRs) are a superfamily of membrane receptors involved in a wide variety of biological processes, and their malfunction is associated with many diseases. Consequently, GPCRs are targeted by one-third of the drugs on the market, and constitute the focus of active public and private research in the search of more effective drugs. READ MORE

  7. 25. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Author : Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. READ MORE