Search for dissertations about: "hot-plate test"

Found 5 swedish dissertations containing the words hot-plate test.

2. 1. Role of calcitonin gene-related peptide in nociception : interactions with substance P and opioids

   Author : Long-Chuan Yu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Calcitonin gene-related peptide CGRP ; CGRP8-37; CGRP-like immunoreactivity; carrageenan; dorsal horn; dorsal root ganglion DRG ; experimentally-induced inflammtion ß-funaltrexamine ß-FNA ; hindpaw withdrawl latency HWL ; hot-plate test; ;

   Abstract : This thesis presents a study of calcitonin gene-related peptide (CGRP) and its antagonist CGRP8-37 and the interactions with substance P and opioids on the transmission of presumed nociceptive information at the spinal cord level in the rat. Significant bilateral increases in hindpaw withdrawal latency (HWL) to heat and mechanical stimulation were induced dose-dependently by intrathecal administration of 5 or 10 but no 1 nmol of CGRP8-37. READ MORE

4. 2. Bilateral neurogenic mechanisms following acute unilateral inflammation

   Author : Indre Bileviciute-Ljungar; Karolinska Institutet; Karolinska Institutet; []
   Keywords : bilateral changes; host defence reaction; contralateral treatment; dorsal root reflexes; cross-spinal reflexes; substance P; neurokinin A; calcitonin gene-related peptide; neuropeptide Y; nociception; inflammation; carrageenan; edema; hindpaw withdrawal latency; microdialysis; hot-plate test; Randall Selitto test;

   Abstract : The contribution of neurogenic mechanisms to inflammation has been extensively studied during the last decade, but provides no clear understanding of the bilateral changes commonly seen following unilateral stimulation. This work demonstrates that bilateral neurogenic mechanisms are a part of general host defence reactions following acute unilateral challenge, for the first time revealing that local anaesthetics applied contralaterally, might be used for therapeutic purposes in relieving pain and inflammation. READ MORE

5. 3. Synthesis and structure activity relationships of competitive NMDA antagonists with analgesic activity

   Author : Britt-Marie Swahn; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

   Abstract : The compounds cis-3-(1-oxo-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 and cis-3-(1-hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 2 were synthesized and found to be potent N-methyl-D-aspartate (NMDA) antagonists. NMR analysis showed that 1 prefers a 2eq,3ax chair conformation probably due to a conformer-stabilizing internal hydrogen bond. READ MORE

6. 4. The role of galanin in chronic pain mechanisms

   Author : Karin Hygge Blakeman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Galanin; galanin receptor 1; pain; neuropathic pain; transgenic mice; knock-out mice; microdialysis;

   Abstract : The general aim of these studies is to further elucidate the role of galanin in pain mechanisms. We have utilized normal and genetically modified animals and a variety of techniques. READ MORE

7. 5. Genetic factors and the role of the NMDA receptor in pain modulation and the effect of opioids

   Author : Aida Plesan; Karolinska Institutet; Karolinska Institutet; []
   Keywords : pain; NMDA-receptor antagonists; genetic difference; rat strain; opioids; methadone; morphine tolerance; neuropathic pain;

   Abstract : Pain perception and the response to opioid analgesics are determined by a number of factors, among which genetic variability and the activation of the NMDA-receptor for glutamate play an important role. The effects of two clinically available NMDA-receptor antagonists, ketamine (KET) and dextromethorphan (DEX), were evaluated on an animal model of acute nociception, the hot plate test, and on human experimental acute ischemic pain. READ MORE