Search for dissertations about: "housekeeping gene"

Showing result 11 - 15 of 22 swedish dissertations containing the words housekeeping gene.

  2. 11. Regulation of Mammalian Poly(A) Polymerase Activity

    Author : Ann-Charlotte Thuresson; Barklie Clements; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; poly A polymerase; PAP; polyadenylation; isoforms; phosphorylation; alternative splicing; CPSF interaction; aminoglycosides; Biomedicin; Microbiology; Mikrobiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Poly(A) polymerase (PAP) is the enzyme catalyzing the synthesis of the adenine tail to the 3’-end of mRNA. This A-tail is present on the majority of the primary RNA transcripts of protein-coding genes, and is important for mRNA stability, export to the cytoplasm and translation. Therefore, PAP is a key regulator of eukaryotic gene expression. READ MORE

  4. 12. Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum

    Author : Ernest Sargsyan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly conserved in mammalian species. The N-terminal domain of ERp29 is similar to the thioredoxin domain of protein disulfide isomerase (PDI) lacking however the double-cysteine active site motif. The C-terminal domain is a novel five-helical fold. READ MORE

  5. 13. Chromatin and transcriptome-based integrative approaches to profile functional long noncoding RNAs - A computational approach

    Author : Santhilal Subhash; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Computational biology; Long noncoding RNAs; Chromatin; S-phase; Cell cycle; sperm; Epigenetics; Histone; cancer; oncogene; Tumor suppressor; DNA methylation; Histone modifications; Chromatin remodelers; lncRNAs; lincRNAs;

    Abstract : One of the major hallmarks of cancer is aberrant or uncontrollable cell division, which occurs due to a defective cell cycle process. During the synthesis phase (S-phase) of the cell cycle, before cell division or mitosis phase, the DNA in the cell makes a new copy to pass on genetic information to the daughter cells. READ MORE

  6. 14. Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants

    Author : Anna-Klara Rundlöf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Redox regulation; thioredoxin reductase; TXNRD1; selenoprotein; promoter; transcription; alternative splicing; expression;

    Abstract : Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. READ MORE

  7. 15. Methods and applications in DNA sequence alignments

    Author : Ellen Sherwood; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA sequence alignment; CNV; Chicken; Trypanosoma cruzi.;

    Abstract : DNA sequence alignment is one of the most common bioinformatics tasks. Alignment analysis for eukaryotic genomes is challenging because the datasets are large. Repeat sequences also make the analysis difficult. This thesis describes new methods which we have developed for DNA sequence alignment that address these problems. READ MORE