Search for dissertations about: "housekeeping gene"

Showing result 16 - 20 of 22 swedish dissertations containing the words housekeeping gene.

  2. 16. Insight into the genetic characteristics of pneumococcal isolates

    Author : Christel Blomberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Streptococcus pneumoniae is a human pathogen and a major contributor to morbidity and mortality worldwide. It has been estimated that it is responsible for between 1-2 million deaths annually. The normal niche for the pneumococci is the nasopharynx where the bacteria can residue for months without causing any symptoms. READ MORE

  4. 17. Hfq- and sRNA-mediated regulation in Neisseria meningitidis

    Author : Jens Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neisseria meningitidis, also known as the meningococcus, is a human-specific pathogen that commonly colonises the nasopharynx without causing disease. For reasons unknown, N. meningitidis can traverse the nasopharyngeal epithelium and enter the bloodstream, causing invasive meningococcal disease manifesting in septicaemia and/or meningitis. READ MORE

  5. 18. Mining DNA elements involved in targeting of chromatin modifiers

    Author : Philge Philip; Per Stenberg; Jan Larsson; Stein Aerts; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleosome; histone; chromatin; chromatin modifiers; targeting; DNA motifs; protein factors; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Background: In all higher organisms, the nuclear DNA is condensed into nucleosomes that consist of DNA wrapped around a core of highly conserved histone proteins. DNA bound to histones and other structural proteins form the chromatin. READ MORE

  6. 19. Identification and evaluation of growth hormone antagonists

    Author : Linda Rosengren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : States in which Growth hormone (GH) levels are elevated have been implicated in several physiological disorders such as acromegaly, diabetic complications and progression of malignancies. Classical treatments for acromegaly are surgery and radiotherapy but also pharmacological therapies exist. READ MORE

  7. 20. Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets

    Author : Nicholas Carl Kristoffer Valerie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on nucleic acid integrity and cellular fitness. In addition to DNA repair mechanisms, these metabolic byproducts are kept in check by so-called sanitation or “housekeeping” enzymes, chief among them the NUDIX hydrolase superfamily. READ MORE