Search for dissertations about: "hplc method development thesis"

Showing result 1 - 5 of 38 swedish dissertations containing the words hplc method development thesis.

  2. 1. Development and improvement of methods for characterization of HPLC stationary phases

    Author : Torgny Undin; Torgny Fornstedt; Jörgen Samuelsson; Anders Törncrona; Johan Ekeroth; Douglas Westerlund; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; Adsorption isotherms; Elution by characteristic points; Inflection points; Single component adsorption; Elution by characteristic points method; Slope data; ECP-slope method; Adsorption; Adsorption energy distribution; Adsorption isotherms; AED; Characterization of adsorption processes; Chromatographic analysis; Chromatography; Hydrophobic-subtraction method HSM ; Hydrophobicity; Linear methods; Linear Models; Liquid chromatography; metoprolol; Non-linear methods; Nonlinear methods; phenol; priority journal; propranolol; Retention mechanism; reversed phase liquid chromatography; Solvation; Subtraction method; Thermodynamics; Chemistry with specialization in Surface Biotechnology; Kemi med inriktning mot ytbioteknik;

    Abstract : High Performance Liquid Chromatography (HPLC) is a widely used tech-nique both for detecting and purifying substances in academy and in the industry. In order to facilitate the use of, and knowledge in HPLC, character-ization of stationary phases is of utmost importance. READ MORE

  4. 2. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    Author : Johan Lindholm; Torgny Fornstedt; Karin Caldwell; Karl-Gustaf Wahlund; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; Chemistry; Kemi;

    Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE

  5. 3. Adsorption Isotherm Parameter Estimation in Nonlinear Liquid Chromatography

    Author : Patrik Forssén; Bertil Gustafsson; Torgny Fornstedt; Georges Guiochon; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; High performance liquid chromatography HPLC ; Preparative chromatography; Competitive adsorption isotherm parameters; Perturbation peak PP method; Inverse method IM ; Computer simulation; Parameter estimation; Numerical method; Scientific Computing; Beräkningsvetenskap;

    Abstract : This thesis concerns the development and validation of methods for the industrially important area of adsorption isotherm parameter estimation in preparative, nonlinear high performance liquid chromatography (HPLC). Preparative chromatography is a powerful separation method to get pure compounds from more or less complex liquid mixtures, e.g. READ MORE

  6. 4. Mass Spectrometry of Biologically Active Small Molecules : Focusing on polyphenols, alkaloids and amino acids

    Author : Zdeněk Spáčil; Leopold L. Ilag; Frantisek Turecek; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; LC-MS; LDI; Mass spectrometry; HPLC; UHPLC; polyphenols; phenolic acids; BMAA; Separation methods; Separationsmetoder; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Abstract : The foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols (PPs), alkaloids and amino acids published in five appended studies are presented and discussed. READ MORE

  7. 5. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    Author : Joel Tärning; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Abstract : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. READ MORE