Search for dissertations about: "hpt"

Showing result 1 - 5 of 29 swedish dissertations containing the word hpt.

2. 1. Multiple endocrine neoplasia type 1 : clinical and molecular characterization

   Author : Bin Tean Teh; Karolinska Institutet; Karolinska Institutet; []
   Keywords : MEN1; PYGM; loss of heterozygosity; thymic carcinoid; HPT-JT; HRPT2; FIHP; familial acromegaly; tumor suppressor gene.;

   Abstract : This thesis is based on clinicopathologic and genetic studies of MEN1 and MEN1-like syndromes. Linkage to the MENl locus in chromosome 11q13 was confirmed in the largest known MEN1 family and 5 Swedish MEN1 families. An accuracy of >99. READ MORE

4. 2. Genetic background of familial primary hyperparathyroidism

   Author : Andrea Villablanca; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Parathyroid; primary hyperparathyroidism; MEN 1; HPT-JT; FIHP; Menin; Parafibromin; tumour suppressor gene; loss of heterozygosity; mutation analysis; immunohistochemistry;

   Abstract : In this thesis the aim has been to identify and characterise gene(s) involved in familial primary hyperparathyroidism (PHPT). In multiple endocrine neoplasia type 1 (MEN 1), the hyperparathyroidism-jaw tumour syndrome (HPT-JT) and familial isolated hyperparathyroidism (FIHP), in which primary hyperparathyroidism is seen in most or almost all gene carriers. READ MORE

5. 3. Primary Hyperparathyroidism : A Study of Cardiovascular Dysfunction and its Reversibility After Parathyroidectomy

   Author : Inga-Lena Nilsson; Lars-Ove Farnebo; Uppsala universitet; []
   Keywords : Medical sciences; primary hyperparathyroidism; vascular endothelium; heart; heart rate variability; blood pressure; parathyroidectomy; calcium; parathyroid hormone; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Surgery; kirurgi;

   Abstract : Cardiovascular risk in primary hyperparathyroidism (HPT) is controversial, and studies mainly from Europe associate HPT with increased cardiovascular morbidity and mortality. Cardiovascular morphology and function were evaluated prospectively in 31 consecutive HPT patients (mean serum calcium 2.97±0. READ MORE

6. 4. Primary hyperparathyroidism of postmenopausal women : Prospective population-based case-control analysis on prevalence, clinical findings and treatment

   Author : Ewa Lundgren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; primary hyperparathyroidism; prevalence; symptoms; morbidity; and treatment; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Abstract : The need of prospective studies on prevalence, clinical features and treatment of mild primary hyperparathyroidism (HPT) has been emphasised. Population-based screening was performed in 5 202 women attending screening mammography at 55-75 years of age. HPT was diagnosed in 2.1% of the women, and almost one third of them were normocalcemic. READ MORE

7. 5. Molecular and clinical genetic studies of a novel variant of familial hypercalcemia

   Author : Eva Szabo; Jan Zedenius; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; hyperparathyroidism; calcium receptor; hypercalcemia; allelic loss; autosomal inheritance; Kirurgi; Surgery; Kirurgi; Kirurgi; Surgery;

   Abstract : Familial primary hyperparathyroidism (HPT) is a rare disorder that is treated surgically and mostly occurs in association with tumor-susceptibility syndromes, like multiple endocrine neoplasia and the hyperparathyroidism-jaw tumor syndrome. Familial hypercalciuric hypercalcemia (FHH) is another cause of hereditary hypercalcemia that generally is considered to require no treatment and is genetically and pathophysiologically distinct from HPT. READ MORE