Search for dissertations about: "human Presequence Protease"
Found 3 swedish dissertations containing the words human Presequence Protease.
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1. Mitochondria in Alzheimer's Disease : The Presequence Protease and Mitochondria-Associated ER Membranes
Abstract : Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative disorders and the accumulation of the amyloid-β peptide (Aβ) in the temporal lobe has been implicated in the pathology of AD. Synaptic transmission in neuronal cells is a highly energy dependent process, which relies on the presence and proper function of mitochondria. READ MORE
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2. Functional and structural studies of the Presequence protease, PreP
Abstract : AtPreP (Arabidopsis thaliana Presequence Protease) is a zink metallooligopeptidase that is dually targeted to both mitochondria and chloroplasts. In these organelles it functions as a peptidasome that degrades the N-terminal targeting peptides that are cleaved off from the mature protein after protein import, as well as other unstructured peptides. READ MORE
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3. The Mitochondrial Peptidasome, PreP, relation to Alzheimer Disease
Abstract : Amyloid-β (Aβ) is the toxic peptide implicated in the pathogenesis of Alzheimer Disease (AD). Accumulation of Aβ has been shown in brain mitochondria from AD patients and AD mice models. The occurrence of Aβ in the mitochondrial matrix leads to free radical generation and apoptosis in neurons. READ MORE