Search for dissertations about: "human Rad51"

Showing result 1 - 5 of 8 swedish dissertations containing the words human Rad51.

  1. 1. Expression and regulation of Rad51 in human cells

    University dissertation from Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Author : Jenny Flygare; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HsRad51 recombination; DNA repair; cell cycle; apoptosis; caspase-3; hybridization array;

    Abstract : Double strand breaks (DSBs) can be caused by exogenous DNA damaging agents or by endogenous processes, and may lead to chromosomal breakage and rearrangement resulting in apoptosis or turnorigenesis. The repair of DSBs in higher eukaryotes is to a large extent accomplished by homologous recombination (HR), a process in which DNA from a complementary strand is used as a template for repair synthesis. READ MORE

  2. 2. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State

    University dissertation from Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Author : Anna Reymer; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molecular modelling; intercalation; homologous recombination; DNA; ruthenium II polypyridyl compounds; human Rad51;

    Abstract : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. READ MORE

  3. 3. Aspects of DNA Strand Exchange: Recombination Proteins and Model System Studies

    University dissertation from Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Author : Karolin Frykholm; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA strand exchange; cationic liposome; Rad51; Site-Specific Linear Dichroism; RecA; molecular crowding;

    Abstract : DNA recombination is of fundamental importance to all living cells; it is part of the DNA repair machinery and a means to generate genetic diversity. DNA strand exchange, the exchange of strands between homologous DNA molecules, is the central reaction of the recombination process. READ MORE

  4. 4. The exosome and the maintenance of genome integrity

    University dissertation from Stockholm : Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University

    Author : Judit Domingo Prim; Neus Visa; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The RNA exosome acts on different RNA substrates and plays important roles in RNA metabolism. The fact that short non-coding RNAs are involved in the DNA damage response led us to investigate whether the exosome plays a role in DNA repair. READ MORE

  5. 5. Replication Fork Stability in Mammalian Cells

    University dissertation from Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University

    Author : Ingegerd Elvers; Thomas Helleday; Jan H. J. Hoeijmakers; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; replication fork progression; replication fork stability; re-priming; DNA damage signalling; NATURAL SCIENCES; NATURVETENSKAP; molekylärgenetik; Molecular Genetics;

    Abstract : Maintaining replication fork integrity is vital to preserve genomic stability and avoid cancer. Physical DNA damage and altered nucleotide or protein pools represent replication obstacles, generating replicative stress. Numerous cellular responses have evolved to ensure faithful DNA replication despite such challenges. READ MORE