Search for dissertations about: "human antimicrobial peptide LL-37"

Showing result 1 - 5 of 32 swedish dissertations containing the words human antimicrobial peptide LL-37.

  1. 1. LL-37-derived cyclic antimicrobial drug leads : Design, synthesis, activity and different ways of creating them 

    Author : Taj Muhammad; Ulf Göransson; Sunithi Gunasekera; Adam A. Strömstedt; Wang Guangshun; Uppsala universitet; []
    Keywords : antimicrobial peptide; host defense; antimicrobial; LL-37; KR-12; peptide cyclisation; peptide dimerisation; croos-linking; cyanobactin-macrocyclase; PatGmac; butelase 1; enzymatic cyclisation; immobilisation; Farmakognosi; Pharmacognosy;

    Abstract : In an era where last-line antibiotics are failing, one of the powerful approaches to develop novel therapeutic agents is to turn back to nature in order to identify possible drug candidates. Among the potential candidates, antimicrobial peptides (AMPs) have garnered much attention as an antimicrobial. READ MORE

  2. 2. Functional dualism of antimicrobial host defence peptides

    Author : Åse Björstad; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Abstract : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. READ MORE

  3. 3. Antimicrobial peptides and virulence factors in meningococcal colonisation and disease

    Author : Miriam Geörg; Ann-Beth Jonsson; Ole E. Sørensen; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Neisseria meningitidis; antimicrobial peptide; LL-37; cell-penetrating peptide; resistance; polynucleotide phosphorylase; molekylär biovetenskap; Molecular Bioscience;

    Abstract : The Gram-negative bacterium Neisseria meningitidis is a transient commensal of the human nasopharynx, but occasionally causes life-threatening disease. During colonisation of its niche, N. meningitidis has to overcome innate immune defences, including the expression of antimicrobial peptides (AMPs). READ MORE

  4. 4. Vascular actions of antimicrobial peptides

    Author : Cristina Ciornei; Sektion II; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vascular smooth muscle; sepsis; nitric oxide; human antimicrobial peptide LL-37; Antimicrobial peptides; lipopolysaccharide; bactericidal permeability-increasing protein;

    Abstract : The present thesis focuses on the vascular effects of antimicrobial peptides especially mechanisms involving the vasodilator nitric oxide (NO), which is released from the blood vessel wall during inflammatory conditions such as sepsis. Bacterial lipopolysaccharide stimulates the expression of nitric oxide synthase (iNOS), which increases the NO production in vascular tissues or cultured vascular smooth muscle cells (VSMC). READ MORE

  5. 5. Actions of Antimicrobial Peptides and Bacterial Components in Inflammation

    Author : Thorgerdur Sigurdardottir; Anestesiologi och intensivvård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; LL-37; M1 protein; S. pyogenes; Toll-like receptors; phenylephrine; nitr1c oxide; antimicrobial peptides;

    Abstract : Antimicrobial peptides are evolutionally ancient parts of the innate immune system and their primary role is to protect us from infections. The human cathelicidin-derived antimicrobial peptide, LL-37, not only possesses broad spectrum antimicrobial activities but is also able to bind and neutralize bacterial lipopolysaccharide (LPS), an important trigger of the widespread inflammatory response contributing to septic shock. READ MORE