Search for dissertations about: "human cytomegalovirus"

Showing result 11 - 15 of 55 swedish dissertations containing the words human cytomegalovirus.

  2. 11. Novel Procedures for Identification and Characterization of Viral Proteases Inhibitors

    Author : Angelica Ehrenberg; Helena Danielson; Celia Schiffer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; drug discovery; viral proteases; inhibitors; Hepatitis C; NS3; cytomegalovirus; Biokemi; Biochemistry;

    Abstract : Viral proteases are often considered to be attractive drug targets because of their crucial function in the viral replication machinery. In order to increase our knowledge of these important targets and to contribute to the discovery and development of new antiviral drugs, the proteases from hepatitis C virus (HCV) and human cytomegalovirus (HCMV) have been produced and their interactions with inhibitors and fragments have been characterized, using enzyme inhibition and SPR biosensor based interaction assay. READ MORE

  4. 12. Human monoclonal antibody technology. A tool to investigate human antibody repertoires

    Author : Mats Ohlin; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The development of technologies to generate cell lines producing monoclonal antibodies of human origin has a great impact on the ability to study repertoires of specificities in the humoral immune response. Furthermore, it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications and which lack some of the disadvantages of similar murine antibodies. READ MORE

  5. 13. Immune evasion of human cytomegalovirus : studies of UL18 and US2 function

    Author : Claudia Wagner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The β-herpes virus cytomegalovirus (HCMV) infects human populations at a high frequency worldwide. Primary infection with HCMV, usually asymptomatic, is followed by lifelong latency. During the long co-evolution of virus and host, a fine balance has developed between viral immune evasion strategies and defence mechanisms of the immune system. READ MORE

  6. 14. Human cytomegalovirus : from novel strain, miRNAs to interplay with breast cancer

    Author : Abdul Aleem Mohammad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The prevalence of human cytomegalovirus (HCMV) ranges from 40% to 100% worldwide. A primary HCMV infection results in a lifelong latent or persistent infection. READ MORE

  7. 15. Human cytomegalovirus in congenital infections and embryonal malignancies of the nervous system

    Author : Nina Wolmer Solberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytomegalovirus (CMV) is a herpesvirus that may cause severe or even fatal disease in immunocompromised patients as well as severe developmental disturbances in foetuses infected in utero. In contrast, only mild symptoms are generally observed in immunocompetent individuals. Virus infections are very common in and the global prevalence is 70-90%. READ MORE