Search for dissertations about: "human gingival fibroblasts"

Showing result 1 - 5 of 14 swedish dissertations containing the words human gingival fibroblasts.

  1. 1. Osteotropic cytokines : expression in human gingival fibroblasts and effects on bone

    Author : Py Palmqvist; Andersson Göran; Umeå universitet; []
    Keywords : osteoblasts; osteoclasts; fibroblasts; cytokines; IL-6; LIF; OSM; IL-4; IL-3; bone resorption; odontologi; Odontology;

    Abstract : Bone metabolism is regulated by endocrine and paracrine signalling molecules influencing bone cells in the continuously remodelling bone tissue. These molecules include a variety of osteotropic stimulatory and inhibitory cytokines. READ MORE

  2. 2. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Author : Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Abstract : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. READ MORE

  3. 3. Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts

    Author : Helena Domeij; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Matrix metalloproteinases; tissue inhibitor of metalloproteinases; gingival fibroblasts; monocytes; periodontal diseases;

    Abstract : Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. READ MORE

  4. 4. Studies on uptake and effect of triclosan on production of inflammatory mediators in human gingival fibroblasts

    Author : Manal Mustafa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Triclosan; gingival fibroblasts; IL-beta; IFN-gamma; MHC class II; PGE2; mPGES-1;

    Abstract : Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is a lipid soluble anti-bacterial agent widely used in dentifrices, mouthrinses, soap and cosmetics. Although reports on the efficacy of triclosan on periodontal diseases are conflicting, it is documented in clinical studies that dentifrices containing triclosan reduce plaque accumulation and improve gingival health. READ MORE

  5. 5. Cyclosporin A-induced gingival overgrowth in renal transplant patients : A clinical, histological and experimental study

    Author : Biniyam Wondimu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; cyclosporin A gingival overgrowth gingival fibroblasts nephrotoxicity renal transplant saliva;

    Abstract : Cyclosporine A (CsA) is widely used as an effective immunosuppressive agent to prevent rejection of organ transplants, as well as in the treatment of patients with various autoimmune diseases. The clinical use of CsA, however, is associated with adverse side effects, including nephrotoxicity, hepatotoxicity, hypertension, and neurotoxicity as well as gingival overgrowth. READ MORE