Search for dissertations about: "human hepatocytes"

Showing result 1 - 5 of 64 swedish dissertations containing the words human hepatocytes.

  1. 1. Proteomics-informed analysis of drug disposition in the human liver and small intestine

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christine Wegler; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; protein concentration; drug disposition; drug transport; drug metabolism; human small intestine; human liver; human hepatocytes; human liver microsomes; inter-individual variability; drug clearance; obesity; prediction model; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. READ MORE

  2. 2. Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nidal Ghosheh; Göteborgs universitet.; Gothenburg University.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human pluripotent stem cells; gene transcription; gene regulation; DNA methylation; transcriptome; hepatocytes;

    Abstract : Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to recapitulate drug metabolism. READ MORE

  3. 3. In vitro toxicity testing using human pluripotent stem cell derivatives

    University dissertation from University of Gothenburg

    Author : Gustav Holmgren; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicity testing; human pluripotent stem cells; cardiomyocytes; hepatocytes; microarray; quantitative proteomics; bioinformatics; transcriptomics; microRNA; Medical sciences; Medicin;

    Abstract : .... READ MORE

  4. 4. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Vildhede; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OATP1B1; OATP1B3; OATP2B1; NTCP; drug transporters; human hepatocytes; atorvastatin; pitavastatin; proteomics; sandwich-cultured human hepatocytes; SCHH; mechanistic modeling; in vitro-in vivo extrapolation; transport inhibition; hepatic uptake; hepatocyte isolation; transporter contribution; Biopharmaceutics; Biofarmaci;

    Abstract : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. READ MORE

  5. 5. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Magnus Ölander; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; drug disposition; ADMET; drug transport; drug metabolism; hepatotoxicity; small intestine; liver; caco-2; human hepatocytes; cryopreservation; apoptosis; liver zonation; non-parenchymal cells; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. READ MORE