Search for dissertations about: "human hepatocytes"
Showing result 16 - 20 of 80 swedish dissertations containing the words human hepatocytes.
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16. Novel human in vitro systems for studies of drug inducted hepatotoxicity
Abstract : Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug discovery, being one of the most common reasons for regulatory actions, including boxed warnings, restricted marketing and withdrawals of marketed drugs. READ MORE
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17. Human amnion epithelial stem cells as a therapy for liver disease
Abstract : Placenta-derived stem cells have been proposed as potential new treatments for acute and congenital liver diseases. Of all the different perinatal tissues, amnion membrane and isolated amnion epithelial cells have been shown to be an outstanding readily available source of multipotent stem cells. READ MORE
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18. Human liver in vitro models for evaluation of drug metabolism and disposition
Abstract : The administrated dose of a drug is adjusted to give a therapeutic effect in patients without causing side-effects or toxicity. Cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes, uptake and efflux transporters and nuclear receptors regulating these enzymes, expressed in the liver and in other tissues, are all important players in drug metabolism, disposition and elimination. READ MORE
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19. Studies on the molecular regulation of bile acids and lipoproteins in human liver
Abstract : Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only organ capable of a quantitative elimination of cholesterol from the body. READ MORE
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20. Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo
Abstract : The cytochrome P450 (P450) enzymes comprise the most important enzyme system with regard to phase I metabolism of drugs. Induction of P450s can result in decreased plasma concentrations of the drug itself or a coadminstered drug, followed by lack of effect. READ MORE