Search for dissertations about: "human protein atlas"

Showing result 1 - 5 of 40 swedish dissertations containing the words human protein atlas.

  2. 1. Mapping and annotating the mammalian body-wide protein-coding gene expression

    Author : Max Karlsson; Mathias Uhlén; Linn Fagerberg; Julio Saez-Rodriguez; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein; protein-coding; genes; annotation; atlas; scRNA-Seq; RNA-Seq; transcriptomics; proteomics; Biotechnology; Bioteknologi;

    Abstract : A central aim of fundamental research is to create conditions necessary for fueling further research and innovation. Our understanding of basic biology is central for future developments of tools for diagnosing, monitoring, and treating disease. READ MORE

  4. 2. The spatiotemporal protein landscape of human cells

    Author : Lovisa Stenström; Emma Lundberg; Björn Högberg; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Spatial proteomics; Immunofluorescence; Human Protein Atlas; Nucleolus; Cell cycle; Citizen science; Bioteknologi; Biotechnology;

    Abstract : This thesis focuses on the spatiotemporal mapping of proteins at a subcellular level. In other words, determining the cellular location of proteins over time. From a biological point of view, knowledge about protein location is fundamental to understand protein function. READ MORE

  5. 3. Spatial proteome profiling of the compartments of the human cell using an antibody-based approach

    Author : Mikaela Wiking; Emma Lundberg; Björn Önfelt; Torbjörn Gräslund; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fluorescence imaging; Human proteome; Human Protein Atlas; Immunofluorescence; Mitochondria; Organelles; Spatial distribution; Bioteknologi; Biotechnology;

    Abstract : The human cell is complex, with countless processes ongoing in parallel in specialized compartments, the organelles. Cells can be studied in vitro by using immortalized cell lines that represent cells in vivo to a varying degree. READ MORE

  6. 4. Spatiotemporal characterization of the human proteome

    Author : Diana Mahdessian; Emma Lundberg; Arne Lindqvist; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Spatial proteomics; Spatiotemporal proteomics; Immunofluorescence; Human Protein Atlas; Cell compartments; Single cell proteomics; Cell cycle; Cancer;

    Abstract : Characterizing the molecular components of the basic unit of life; the cell, is crucial for a complete understanding of human biology. The cell is divided into compartments to create a suitable environment for the resident proteins to fulfill their functions. READ MORE

  7. 5. Proteome wide protein production

    Author : Hanna Tegel; Sophia Hober; Diethard Mattanovich; KTH; []
    Keywords : protein production; Escherichia coli; transcription; promoter; translation; rare codon; high-throughput; screening;

    Abstract : Over a decade after the completion of the human genome, researchers around the world are still wondering what information is hidden in the genome. Although the sequences of all human genes are known, it is still almost impossible to determine much more than the primary protein structure from the coding sequence of a gene. READ MORE