Search for dissertations about: "human toxicity"

Showing result 1 - 5 of 301 swedish dissertations containing the words human toxicity.

  2. 1. Environmental and health hazards of chemicals in plastic polymers and products

    Author : Delilah Lithner; Göteborgs universitet; []
    Keywords : plastics; plastic products; plastic polymers; consumer products; environmental hazards; environment; health hazards; human health; hazard ranking; hazard assessment; chemical ranking; hazard identification; hazard classifications; hazardous chemicals; hazardous substances; toxic substances; monomers; polymers; toxicity; acute toxicity; toxicity tests; Daphnia magna; Toxicity Identification Evaluation; TIE; leaching; leachates; product leachates; leaching tests; plastic materials; plastic;

    Abstract : Plastics are extremely diverse in terms of chemical composition, properties and possible applications, and are widely distributed in the society and the environment. In the last 15 years the global annual production has doubled, reaching 245 million tons in 2008. READ MORE

  4. 2. Towards new computational tools for predicting toxicity

    Author : Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

    Abstract : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. READ MORE

  5. 3. Proteomics informed investigation of human hepatocytes and liver tissue

    Author : Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. READ MORE

  6. 4. Aldehyde toxicity in human oral epithelium

    Author : Jan Anders Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Oral epithelium; cell cultures; toxicity; transformation; aldehydes; thiols; ADH3;

    Abstract : Human oral epithelium is an established target for aldehyde toxicity, including from usage of tobacco, intake of foods and fluids, leaching of dental materials, and from mouth inhalation of aldehydes in the work environment. Following establishment of culture/exposure protocols for oral cell cultures, toxicity mechanisms and risk of malignant transformation from aldehyde exposure was investigated, including the metabolic defense offered by alcohol dehydrogenase 3 (ADH3) against formaldehyde toxicity. READ MORE

  7. 5. In vitro toxicity testing using human pluripotent stem cell derivatives

    Author : Gustav Holmgren; Anders Lindahl; Jane Synnergren; Peter Sartipy; Chris Denning; Sahlgrenska Academy at University of Gothenburg; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicity testing; human pluripotent stem cells; cardiomyocytes; hepatocytes; microarray; quantitative proteomics; bioinformatics; transcriptomics; microRNA; Medical sciences; Medicin; Bioinformatik; Bioinformatics;

    Abstract : .... READ MORE