Search for dissertations about: "human tumour cell"

Showing result 1 - 5 of 214 swedish dissertations containing the words human tumour cell.

  1. 1. Cyclin E overexpression and associated events in human breast cancer

    Author : Maria Stighall; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; tumour growth pattern; invasion; proliferation; ID2; cyclin E; pRb; cell cycle; breast cancer;

    Abstract : Unrestrained proliferation is a hallmark of cancer and genetic defects within G1/S-phase regulation and the pRb pathway occur frequently. Proliferation control can be circumvented either by excess cyclin D1 or cyclin E, alterations that can define two alternative tumour biologic pathways in breast cancer. READ MORE

  2. 2. Human cytokeratins : their use as targets in cancer management

    Author : Birgitta Sundström; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cytokeratins, biochemically related to intermediate filaments (IF), form an intracellular network of filaments which contributes to the mechanical stabilizing of the cell. 19 individual polypeptides, divided into two groups, constitute the cytokeratin family. READ MORE

  3. 3. Regulation of apoptosis during treatment and resistance development in tumour cells

    Author : Jeanette Blomberg; Erik Lundgren; John Eriksson; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumörbiologi; Tumour biology; Tumörbiologi;

    Abstract : Induction of apoptosis is the most studied cell death process and it is a tightly regulated physiological event that enables elimination of damaged and unwanted cells. Apoptosis can be induced via activation of either the intrinsic or the extrinsic signalling pathway. READ MORE

  4. 4. Pancreatic Endocrine Tumourigenesis : Genes of potential importance

    Author : Térèse A. Johansson; Barbro Eriksson; Britt Skogseid; Gunnar Westin; Martin Bäckdahl; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic endocrine tumour; Multiple endocrine neoplasia type 1; Tumourigenesis; Notch signalling; Notch1; Hes1; Neurog3; Neurod1; Men1; Ascl1; Pou3f4; Pdx1; Rpl10; Dlk1; Dkk1; Tph1; menin; Tumour biology; Tumörbiologi;

    Abstract : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. READ MORE

  5. 5. Studies of Stroma Formation and Regulation in Human Pathological Conditions and in Experimental in vivo Models

    Author : Alejandro Rodriguez; Christian Sundberg; Kristian Pietras; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; Tumor Stroma; Myofibroblast; Pericyte; Angiogenesis; Inflammation; adenovirus; Tumour biology; Tumörbiologi; Molecular medicine; Molekylär medicin; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Fibrosis is a sequel of chronic inflammation and is defined as an excessive deposition of collagen that ultimately leads to organ dysfunction. To date there are no effective treatments for fibrosis. The main cell type involved in collagen deposition and organization is the myofibroblast. READ MORE