Search for dissertations about: "huntingtin"
Showing result 1 - 5 of 22 swedish dissertations containing the word huntingtin.
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1. Mechanisms underlying metabolic alterations in Huntington's disease. Beyond the brain and back
Abstract : Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. READ MORE
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2. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease
Abstract : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. READ MORE
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3. β-cell dysfunction in Huntington's disease
Abstract : Huntington's disease (HD), a fatal neurodegenerative disorder, is associated with an increased risk of diabetes mellitus. The reason for this is unknown, but considering the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. READ MORE
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4. New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes
Abstract : Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. READ MORE
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5. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease
Abstract : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. READ MORE