Search for dissertations about: "hyaluronan"

Showing result 1 - 5 of 88 swedish dissertations containing the word hyaluronan.

  1. 1. Kidney Hyaluronan Regulatory Aspects During Different States of Body Hydration, Nephrogenesis & Diabetes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Louise Rügheimer; Uppsala universitet.; [2008]
    Keywords : Physiology; hyaluronan; kidney; dehydration; hydration; diabetes; nephrogenesis; renomedullary interstitial cells; CD44; hyaluronan synthase; hyaluronidase; vasopressin; nitric oxide; prostaglandins; glucocorticoids; angiotensin II; diuresis; lymph vessel; podoplanin; Fysiologi;

    Abstract : The kidney regulates the excretion of water and electrolytes, which maintains homeostasis and enables control of arterial blood pressure. Hyaluronan, a large negatively charged interstitial glucosaminoglycan, is heterogeneously distributed within the kidney, primarily found in the medulla. READ MORE

  2. 2. About hyaluronan in the hypertrophic heart studies on coordinated regulation of extracellular matrix signalling

    University dissertation from Umeå : Umeå universitet

    Author : Urban Hellman; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE

  3. 3. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Merima Mehić; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; TGFβ; PDGF-BB; cancer; signaling; hyaluronan synthase; epithelial-mesenchymal transition; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Medical Science; Medicinsk vetenskap;

    Abstract : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. READ MORE

  4. 4. Hyaluronan and Renal Fluid Handling Studies during Normal and Pathological Conditions of Renal Function

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Viktoria Göransson; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; CD44; gerbils; hyaluronan; ischemia-reperfusion; kidney; osmolality; oxygen tension; rat; renomedullary interstitial cells; water; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; Physiology; fysiologi;

    Abstract : The kidney is the major organ responsible for the regulation of the composition and volume of the body fluids, which is essential for homeostasis. The glycosaminoglycan hyaluronan (HA), with extreme water-binding capacity, is present in the interstitium of the kidney with a heterogenous distribution. READ MORE

  5. 5. Extracellular matrix as a regulator of cell behavior : Biological effects of hyaluronan biosynthesis and catabolism

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mehdi Rahmanian; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Hyaluronan; hyaluronidase; CD44; Biokemi; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : Extracellular matrix surrounding cells is an important regulator of cellular functions. Hyaluronan (HA) is a glycosaminoglyean and a constituent component of the extracellular matrix in all tissues. It is synthesized by hyaluronan syntheses (HAS) at the inner surface of cell membrane and degraded by hyaluronidases to small fragments. READ MORE