Search for dissertations about: "hyaluronan"

Showing result 16 - 20 of 99 swedish dissertations containing the word hyaluronan.

  2. 16. Role of TGFβ-induced hyaluronan-CD44 signaling in cancer progression

    Author : Constantinos Kolliopoulos; Evi Heldin; Aristidis Moustakas; Jonathan Sleeman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hyaluronan; CD44; TGFβ; cancer; EMT; signal transduction; transcriptional regulation;

    Abstract : Hyaluronan, a prevalent glycosaminoglycan of the extracellular space often accumulates in pathological conditions, such as chronic inflammation, infection, and cancer. Hyaluronan synthase HAS2 has been responsible for the synthesis and deposition of hyaluronan in a variety of tumors. READ MORE

  4. 17. Hyaluronan receptors of liver endothelial cells, their purification and characterisation

    Author : Peter A. G. McCourt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; scavenger receptors; ICAM-1; liver endothelial cells; Biokemi; Biochemistry; Biokemi; fysiologi; Physiology;

    Abstract : Hyaluronan (HA) is a polysaccharide common throughout the connective tissues. and is found at low concentrations in the blood. The major site of its clearance is via an endocytic receptor on liver endothelial cells (LEC). This process is vital, as excessive serum levels of HA lead to clotting disorders and overly viscous blood. READ MORE

  5. 18. Modular Hyaluronan-Based Hydrogels for 3D Cell Culture and Bioprinting

    Author : Michael Jury; Daniel Aili; Robert Selegård; My Hedhammar; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hyaluronan; 3D cell-culture; Biofunctionality; Bioprinting;

    Abstract : Three-dimensional (3D) cell culture facilitates development of biological relevant assays for drug screening and toxicity testing. Compared to conventional 2D cell culture, cells cultured in 3D can more accurately mimic human tissues and organs and thus provide ex vivo data with potentially better predictive value for cancer research, pharmacology, and toxicology, reducing the need for animal models, improving experimental reproducibility, and reducing time and costs in drug development. READ MORE

  6. 19. Effect of Hyaluronan-activation of CD44 on Cell Signaling and Tumorigenesis

    Author : Lingli Li; Paraskevi Heldin; Raija H. Tammi; Uppsala universitet; []
    Keywords : Biomedicine; Hyaluronan; CD44; growth factors; chemokines; tumorigenesis; wound healing; cell signaling; Biomedicin;

    Abstract : Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a signaling molecule. It is important during various biological activities such as embryogenesis, angiogenesis, wound healing and tumor progression. READ MORE

  7. 20. Hyaluronan and the receptor CD 44 in the heart and vessels : a study in normal and pathological conditions

    Author : Martin Hellström; Anna Engström-Laurent; Bengt Johansson; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; CD44; heart; Rat; cardiac hypertrophy; artery; vein; human; Medicine; medicin;

    Abstract : Tissues are not solely composed of cells. The extracellular matrix is important for the cell well-being and cell-cell communication. The glycosaminoglycan hyaluronan (HYA) is a widely distributed extracellular matrix (ECM) component. READ MORE