Search for dissertations about: "hyaluronan"

Showing result 21 - 25 of 99 swedish dissertations containing the word hyaluronan.

  2. 21. The role of hyaluronan and its CD44 receptor in inflammation and cancer

    Author : Chun-Yu Lin; Jyrki Tenhunen; Miklós Lipcsey; Paraskevi Heldin; Markku Tammi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD44; Dengue; Hyaluronan; HAS2; iASPP; TGFbeta; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Hyaluronan, an important extra-cellular matrix molecule, was thought to be interstitial connecting glue decades ago. However, recent evidence has revealed that hyaluronan and its binding proteins also play crucial roles in various pathophysiological conditions in humans, including inflammation and infection. READ MORE

  4. 22. Impaired reparative processes in particular related to hyaluronan in various cutaneous disorders : a structural analysis

    Author : Ulf Bertheim; Bengt Gerdin; Umeå universitet; []
    Keywords : hyaluronan; scar tissue; diabetes mellitus; basal cell carcinoma; skin; wound healing; Oto-Rhino-Laryngology; oto-rhino-laryngologi;

    Abstract : Cutaneous reparative processes, including wound healing, are highly developed procedures in which a chain of actions occurs to reconstitute the function of the wounded tissue. To prevent a delayed or excessive reparative process it is important to understand how this procedure develops and is maintained. READ MORE

  5. 23. The expression and regulation of hyaluronan synthases and their role in glycosaminoglycan synthesis

    Author : Jonas Brinck; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; hyaluronan; glycosaminoglycans; CD44; growth factors; UDP-glucose dehydrogenase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : The glycosaminoglycan hyaluronan is an essential component of the extracellular matrix in all higher organisms, affecting cellular processes such as migration, proliferation and differentiation. Hyaluronan is synthesized by a plasma membrane bound hyaluronan synthase (HAS) which exists in three genetic isoforms. READ MORE

  6. 24. Experimental Models of the Human Peritoneal Environment: Effects of TGF-beta and Hyaluronan

    Author : Peter Falk; Göteborgs universitet; []
    Keywords : Adhesion formation; experimental model; cell culture; mesothelial cells; peritoneum; fibrinolytic system; transforming growth factor beta; hyaluronan; proliferation;

    Abstract : BACKGROUND Post surgical adhesion formation is still an unsolved problem and occurs when there is an imbalance between fibrin deposition and fibrin clearing capacity in the abdominal cavity. Transforming growth factor beta (TGF-?) is associated with fibrosis and hyaluronan has in several studies been showed to reduce adhesions. READ MORE

  7. 25. Hyaluronan in malignant pleural mesothelioma with special reference to diagnosis, tumourbiology and prognosis

    Author : Anders Thylén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Malignant pleural mesothelioma; hyaluronan; prognosis; methods; immunohistochemistry; tumourvolume; chemotherapy; tirapazamine; cisplatin;

    Abstract : Malignant pleural mesothelioma (MPM), the primary malignant tumour of the pleural cavity, is an uncommon and treatment resistant tumour. The prognosis is poor. In many, but not all cases the concentration of hyaluronan (Hya) is increased in pleural effusion. The clinical relevance of Hya in MPM is not clear. READ MORE