Search for dissertations about: "hyaluronidase"

Showing result 1 - 5 of 7 swedish dissertations containing the word hyaluronidase.

  2. 1. Extracellular matrix as a regulator of cell behavior : Biological effects of hyaluronan biosynthesis and catabolism

    Author : Mehdi Rahmanian; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Hyaluronan; hyaluronidase; CD44; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Abstract : Extracellular matrix surrounding cells is an important regulator of cellular functions. Hyaluronan (HA) is a glycosaminoglyean and a constituent component of the extracellular matrix in all tissues. It is synthesized by hyaluronan syntheses (HAS) at the inner surface of cell membrane and degraded by hyaluronidases to small fragments. READ MORE

  4. 2. Kidney Hyaluronan : Regulatory Aspects During Different States of Body Hydration, Nephrogenesis & Diabetes

    Author : Louise Rügheimer; Peter Hansell; Cecilia Johnsson; Örjan Källskog; Mats Rundgren; Uppsala universitet; []
    Keywords : Physiology; hyaluronan; kidney; dehydration; hydration; diabetes; nephrogenesis; renomedullary interstitial cells; CD44; hyaluronan synthase; hyaluronidase; vasopressin; nitric oxide; prostaglandins; glucocorticoids; angiotensin II; diuresis; lymph vessel; podoplanin; Fysiologi;

    Abstract : The kidney regulates the excretion of water and electrolytes, which maintains homeostasis and enables control of arterial blood pressure. Hyaluronan, a large negatively charged interstitial glucosaminoglycan, is heterogeneously distributed within the kidney, primarily found in the medulla. READ MORE

  5. 3. Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling

    Author : Helena Porsch; Paraskevi Heldin; Véronique Orian-Rousseau; Uppsala universitet; []
    Keywords : extracellular matrix; growth factor; hyaluronan synthase; hyaluronidase; epithelial-mesenchymal transition; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor. Overexpression of the glycosaminoglycan hyaluronan, and its adhesion receptor CD44, correlate with breast cancer progression. READ MORE

  6. 4. Hyaluronan and Renal Fluid Handling : Studies during Normal and Pathological Conditions of Renal Function

    Author : Viktoria Göransson; Mats Rundgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; CD44; gerbils; hyaluronan; ischemia-reperfusion; kidney; osmolality; oxygen tension; rat; renomedullary interstitial cells; water; Cellbiologi; Cell biology; Cellbiologi; Physiology; fysiologi;

    Abstract : The kidney is the major organ responsible for the regulation of the composition and volume of the body fluids, which is essential for homeostasis. The glycosaminoglycan hyaluronan (HA), with extreme water-binding capacity, is present in the interstitium of the kidney with a heterogenous distribution. READ MORE

  7. 5. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro

    Author : Sara Stridh; Peter Hansell; Mats Rundgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

    Abstract : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. READ MORE