Search for dissertations about: "hydration entropy"
Showing result 1 - 5 of 10 swedish dissertations containing the words hydration entropy.
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1. Molecular recognition and dynamics in proteins studied by NMR
Abstract : Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial protein G (PGB1). READ MORE
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2. Challenges in Computational Biochemistry: Solvation and Ligand Binding
Abstract : Accurate calculations of free energies for molecular association and solvation are important for the understanding of biochemical processes, and are useful in many pharmaceutical applications. In this thesis, molecular dynamics (MD) simulations are used to calculate thermodynamic properties for solvation and ligand binding. READ MORE
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3. Computational Analysis of Aqueous Drug Solubility – Influence of the Solid State
Abstract : Aqueous solubility is a key parameter influencing the bioavailability of drugs and drug candidates. In this thesis computational models for the prediction of aqueous drug solubility were explored. READ MORE
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4. On Catalytic Mechanisms for Rational Enzyme Design Strategies
Abstract : Enzymes enable life by promoting chemical reactions that govern the metabolism of all living organisms. As green catalysts, they have been extensively used in industry. However, to reach their full potential, engineering is often required, which can benefit from a detailed understanding of the underlying reaction mechanism. READ MORE
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5. Computer simulation of topological and spatial structure in water and aqueous solutions
Abstract : The present thesis concerns molecular-dynamics and expanded-ensemble simulation of topological and spatial structure in water and aqueous solutions.First, methods for analysis of molecular pair configurations using angularly resolved density distributions were considered. READ MORE