Search for dissertations about: "hydroperoxide isomerase"

Showing result 1 - 5 of 6 swedish dissertations containing the words hydroperoxide isomerase.

  1. 1. A novel fatty acid 8R-dioxygenase and hydroperoxide isomerase : catalytical, pharmacological and biochemical properties of two fungal enzymes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Irene D. Brodowsky; [1994]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  2. 2. Catalytic and Structural Properties of Heme-containing Fatty Acid Dioxygenases Similarities of Fungal Dioxygenases and Cyclooxygenases

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ulrike Garscha; Ernst Oliw; Per-Johan Jakobsson; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dioxygenase; prostaglandin H synthase; Gaeumannomyces graminis; Aspergilli; hydroperoxide isomerase; linoleate diol synthase; cytochrome P450; oxylipin; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : 7,8-Linoleate diol synthase (7,8-LDS) of the take-all pathogen of wheat, Gaeumannomyces graminis, converts linoleic acid to 8R-hydroperoxyoctadecadienoic acid (8-HPODE) by 8-dioxygenase activity (8-DOX), and further isomerizes the hydroperoxide to 7S,8S-dihydroxyoctadecadienoic acid (7,8-DiHODE) by hydroperoxide isomerase activity. Sequence alignment showed homology to prostaglandin H synthase (PGHS), and both enzymes share structural and catalytic properties. READ MORE

  3. 3. Novel Fatty Acid Dioxygenases of Human and Plant Pathogenic Fungi Studies by Gene Deletion and Expression

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Fredrik Jernerén; Ernst Oliw; Ivo Feussner; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aspergilli; dioxygenase; oxygenase; Magnaporthe oryzae; Gaeumannomyces graminis; Lasiodiplodia theobromae; jasmonic acid; linoleate diol synthase; cyclooxygenase; prostaglandin H synthase; cytochrome P450; oxylipin; hydroperoxide isomerase; allene oxide synthase; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

    Abstract : The dioxygenase-cytochrome P450 fusion proteins (DOX-CYP) comprise a heme-containing enzyme family that shares structural and catalytic properties with mammalian prostaglandin H (PGH) synthases. 7,8-Linoleate diol synthase (7,8-LDS) of Gaeumannomyces graminis was first characterized, and DOX-CYP enzymes are of mechanistic and biological interest. READ MORE

  4. 4. Expression of Manganese Lipoxygenase and Site-Directed Mutagenesis of Catalytically Important Amino Acids Studies on Fatty Acid Dioxygenases

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mirela Cristea; Ernst H. Oliw; Chao Su; Olof Rådmark; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Dioxygenase; Gaeumannomyces graminis; lipoxygenase; Magnaporthe grisea; oxylipin; Pichia pastoris; hydroperoxide isomerase; polyunsaturated fatty acids; Farmaceutisk farmakologi; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi;

    Abstract : Polyunsaturated fatty acids can be bioactivated by two families of dioxygenases, which either contain non-heme iron (lipoxygenases) or heme (cyclooxygenases, linoleate diol synthases and α-dioxygenases).Lipoxygenases and their products play important roles in the pathophysiology of plants and fungi. READ MORE

  5. 5. Discovery of Novel Fatty Acid Dioxygenases and Cytochromes P450 Mechanisms of Oxylipin Biosynthesis in Pathogenic Fungi

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Inga Hoffmann; Ernst H Oliw; Alan R Brash; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Fusion protein; Linoleate diol synthase; Allene oxide synthase; Cyclooxygenase; Oxygenase; HPLC; Mass spectrometry; Hydroperoxide isomerase; Aspergillus; Fusarium oxysporum; Pharmaceutical Biochemistry; Farmaceutisk biokemi; Farmaceutisk farmakologi; Pharmaceutical Pharmacology; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Dioxygenase-cytochrome P450 (DOX-CYP) fusion enzymes are present in diverse human and plant pathogenic fungi. They oxygenate fatty acids to lipid mediators which have regula­tory functions in fungal development and toxin production. READ MORE