Search for dissertations about: "hydroxycholesterol"

Showing result 1 - 5 of 41 swedish dissertations containing the word hydroxycholesterol.

  2. 1. Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol

    Author : Hanna Nylén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about 50% of all drugs. READ MORE

  4. 2. Deciphering the role of 27-hydroxycholesterol in neurodegeneration

    Author : Muhammad Al Mustafa Ismail; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol is constantly attributed to neurodegenerative diseases including Alzheimer’s disease (AD). This is due to the association of high blood cholesterol and the consequences of cholesterol metabolism in these conditions. READ MORE

  5. 3. Studies on 7a-hydroxycholesterol in extrahepatic tissues and cells

    Author : Jie Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In human liver, primary bile acids are synthesized from cholesterol via the well-established neutral and also via the recently described acidic pathways. The latter includes 27-hydroxycholesterol 7alpha-hydroxylase. READ MORE

  6. 4. Studies on 4b-hydroxycholesterol, a marker of CYP3A activity, and its association with 25-hydroxyvitamin D

    Author : Hanna Nylén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol is a vital compound that can undergo cytochrome P450 (CYP) mediated conversion into steroid hormones, bile acids and oxysterols. CYP enzymes are present in all human tissues and mediate the metabolism of several endogenous and exogenous compounds such as steroids and drugs. READ MORE

  7. 5. 24s-Hydroxycholesterol : studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration

    Author : Marjan Shafaati; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC). This structural modification allows 24S-OHC to traverse the blood brain barrier and this pathway is the major one for elimination of cholesterol from the mammalian brain. READ MORE