Search for dissertations about: "hydroxylated metabolites"

Showing result 1 - 5 of 18 swedish dissertations containing the words hydroxylated metabolites.

  2. 1. Pharmacokinetics of the enantiomers of thalidomide

    Author : Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. READ MORE

  4. 2. Assessment of Environmental Pollutants in Humans from Four Continents : Exposure levels in Slovakia, Guinea-Bissau, Nicaragua and Bangladesh

    Author : Linda Linderholm; Åke Bergman; Maria Athanasiadou; Kristina Jakobsson; Myrto Petreas; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; POPs; PCB; DDT; PBDE; HCH; metabolites; human exposure; children s exposure; placental transfer; Environmental chemistry; Miljökemi; miljökemi; Environmental Chemistry;

    Abstract : Humans are continuously exposed to complex mixtures of anthropogenic chemicals. This thesis focus on human exposure to persistent organic pollutants (POPs). POPs ability to bioaccumulate and biomagnify together with the extensive historical use of POPs in e.g. READ MORE

  5. 3. Synthesis of organobromines as a tool for their characterisation and environmental occurrence assessment

    Author : Andreas Rydén; Göran Marsh; Vladimir Nikiforov; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Polybrominated diphenyl ethers; Brominated diphenyliodoniums salts; PBDEs; OH-PBDEs; MeO-PBDEs; Synthesis; Analysis; Abbreviations; Metabolites; Marine natural products; E-waste; Brominated flameretardants; miljökemi; Environmental Chemistry;

    Abstract : Polybrominated diphenyl ethers (PBDEs) have been intensively used as flame retardants (FRs) and have become ubiquitous environmental pollutants. PBDEs form hydroxylated PBDEs (OH-PBDEs) as metabolites. Further, some OH-PBDEs and methoxy-PBDEs (MeO-PBDEs) are natural products. READ MORE

  6. 4. Identification and Characterisation of Hydroxylated PCB and PBDE Metabolites in Blood : Congener specific synthesis and analysis

    Author : Tina Malmberg; Åke Bergman; Olov Sterner; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi;

    Abstract : Hydroxylated polychlorinated biphenyls (OH-PCBs) are known metabolites of polychlorinated biphenyls (PCBs) in many mammalian, bird and fish species. Among those, certain OH-PCB congeners are strongly localised in the blood compartment of humans and wild animals. READ MORE

  7. 5. Exposure and effects of naturally produced hydroxylated polybrominated diphenyl ethers in fish : Implications for Baltic Sea wildlife

    Author : Johan Gustafsson; Lillemor Asplund; Pim E.G. Leonards; Marja H. Lamoree; Robert Letcher; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ecotoxicology; Metabolomics; OH-PBDE; Algae; Cyanobacteria; Natural products; Thiamine; Health; Biomarker; Seasonal variation; Perch; Zebrafish; Flame retardant; Mixture; 6-OH-BDE47; Energy metabolism; Endocrine disruption; Neurotoxicity; OXPHOS; Environmental Chemistry; miljökemi;

    Abstract : The aim of this thesis was to investigate if naturally produced hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are causing negative health effects for Baltic Sea wildlife. In the laboratory, OH-PBDEs have shown to be potent disrupters of energy metabolism as well as endocrine disruptors and neurotoxins. READ MORE