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Showing result 1 - 5 of 22 swedish dissertations matching the above criteria.

  2. 1. Validation of Several Nucleoside Tracers as Proliferation Markers

    Author : Li Lu; Sven Reske; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; PET; cell proliferation; DNA synthesis; hydroxyurea; cimetidine; diuretic; Biofarmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Positron emission tomography (PET) is a powerful method for in vivo characterization of tumor biochemistry and clinically has been used for diagnosing and grading of malignancy. A key element in oncology is proliferation potential, a feature that is assumed to be an important indicator of tumor growth. READ MORE

  4. 2. Targeting residual malignant cells in myeloid leukemia

    Author : Malin Nilsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia; chronic myeloid leukemia; histamine dihydrochloride; hydroxyurea; leukemic stem cells;

    Abstract : Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated with leukemic relapse, mostly with dismal survival outcome. READ MORE

  5. 3. Effects of post-treatments with hydroxyurea and caffeine in G2 on the frequency of chromosomal aberrations induced by physical and chemical agents in mammalian cells

    Author : Kerstin Hansson; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  6. 4. Structural and functional studies on ribonucleotide reductase protein B2 from Escherichia coli

    Author : Margareta Karlsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductases; Eshcerichia coli;

    Abstract : Ribonucleotide reductase catalyzes the reduction of ribonucleotidesto the corresponding deoxyribonucleotides, the building blocks forDNA. The enzyme from Escherichia coli consists of two proteins.Bl and B2. Protein B2 contains two dinuclear iron centers and astable tyrosyl radical. READ MORE

  7. 5. Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression

    Author : Ulla Olsson-Strömberg; Bengt Simonsson; Elin Lindhagen; Gisela Barbany; Johan Richter; Uppsala universitet; []
    Keywords : Medicine; chronic myeloid leukemia; adult; stem cell transplantation; mobilization of Ph-negative stem cells; in vitro assay; imatinib; gene expression; Medicin;

    Abstract : The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by in vitro cytotoxicity assay, and the gene expression pattern in interferon treated patients. READ MORE