Search for dissertations about: "hydroxyurea"

Showing result 16 - 20 of 22 swedish dissertations containing the word hydroxyurea.

  2. 16. The Smc5/6 complex : linking DNA replication with chromosome segregation

    Author : Kristian Jeppsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In order to faithfully propagate the genetic material from one generation to the next, cells need to properly replicate and segregate their chromosomes. The three well-conserved eukaryotic Structural Maintenance of Chromosomes (SMC) protein complexes, cohesin, condensin and the Smc5/6 complex (Smc5/6) organize chromosomes to ensure that the daughter cells receive a full complement of chromosomes. READ MORE

  4. 17. Electron paramagnetic resonance and biochemical studies of red-ox properties of the diferric/radical center in mouse and Mycobacterium tuberculosis ribonucleotide reductase R2 proteins

    Author : Albert Davydov; Marc Fontecave; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Abstract : Ribonucleotide reductase (RNR) catalyses the reduction of all four ribonucleotides to the corresponding deoxyribonucleotides that are used by the cells for DNA synthesis. The active enzyme from mouse, Mycobacterium tuberculosis (M. tuberculosis) and aerobically grown E. READ MORE

  5. 18. Predictors of prognosis in acute myeloid leukemia : a clinical and epidemiological study

    Author : Åsa Rangert Derolf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : AML is a malignant disorder characterized by clonal expansion of immature myeloid hematopoietic stem cells, myeloblasts, in bone marrow, blood and/or other tissue. Despite advances in treatment the majority of patients eventually die from this aggressive disease. READ MORE

  6. 19. Chronic myeloid leukemia and cancer

    Author : Niklas Gunnarsson; Anders Själander; Martin Höglund; Bertil Lindahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukemia; Prevalence; Malignancies; Odds ratio; Standardized Incidence Ratio; Outcome; Autoimmune diseases; Survival; Epidemiology; epidemiologi; medicin; Medicine;

    Abstract : Background Chronic myeloid leukemia (CML) is a relatively rare hematological malignancy with a constant incidence of approximately 90 new cases each year in Sweden (0.9 cases/100 000 inhabitants). The etiology is largely unknown but high doses of ionizing radiation are a known but rare risk factor. READ MORE

  7. 20. Mechanisms behind Smc5/6 transcriptional regulation and cohesin-mediated chromosome organisation

    Author : Stefina Milanova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The eukaryotic family of Structural Maintenance of Chromosomes (SMC) complexes are multi-subunit, ring-like protein complexes and include condensin, cohesin and the Smc5/6 complex (Smc5/6). Considered as an entity, this family is essential for most chromosome-based processes, and protects against diverse human syndromes and diseases. READ MORE