Search for dissertations about: "hyperglucagonemia"

Showing result 1 - 5 of 6 swedish dissertations containing the word hyperglucagonemia.

2. 1. Childhood Obesity and Islet Function

   Author : Johan Staaf; Peter Bergsten; Anders Forslund; Hindrik Mulder; Uppsala universitet; []
   Keywords : type 2 diabetes mellitus; Uppsala Longitudinal Study of Childhood Obesity; palmitate; glucose-stimulated insulin secretion; hyperinsulinemia; hyperglucagonemia; GLP-1; glicentin; magnetic resonance imaging; metabolic syndrome; oral glucose tolerance test; centroid; Pediatrik; Pediatrics;

   Abstract : The prevalence of childhood obesity and Type 2 Diabetes Mellitus (T2DM) has increased during recent decades. T2DM is accompanied with functional changes in the islets of Langerhans, which can be identified early in the pathogenesis. READ MORE

4. 2. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

   Author : Linda Ahlkvist; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

   Abstract : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. READ MORE

5. 3. Insulin-antagonistic neurohormonal pathways in the development of insulin resistance and type 2 diabetes

   Author : Martin Lundqvist; Jan W Eriksson; Niclas Abrahamsson; André van Beek; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucagon; cortisol; ACTH; growth hormone; counter-regulation; clamp; hypoglycemia; hyperglycemia; obesity; type 2 diabetes; inflammation;

   Abstract : According to the current paradigm, the development of type 2 diabetes is driven by insulin resistance and the gradual failure of beta cells to compensate for this by secreting adequate amounts of insulin. Obesity is an important risk factor for type 2 diabetes and is considered to influence disease development primarily by induction of insulin resistance, via mechanisms that have not been fully elucidated. READ MORE

6. 4. Signal Transduction of Glucagon Secretion

   Author : Elaine Vieira; Erik Gylfe; Lena Eliasson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; secretion; glucagon; store-operated channels; calcium; diabetes; Cellbiologi; Cell biology; Cellbiologi;

   Abstract : Diabetes mellitus is a bihormonal disorder with hyperglycemia due to deficiency of insulin and hypersecretion of glucagon. To improve diabetes treatment it is important to clarify the signal transduction of glucagon secretion. READ MORE

7. 5. Islet hormonal hypersecretion and metformin’s effect on islet hormonal secretion studied in vitro and in vivo

   Author : Quan Wen; Anders Forslund; Hannes Manell; Hjalti Kristinsson; Lisa Juntti-Berggren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha cell; carboxypeptidase E; childhood obesity; DRP-1; free fatty acids; glucagon secretion; glucose metabolism; glucose stimulated insulin secretion; human islets; hyperinsulinemia; metformin; mitochondrial fission; oral glucose tolerance test OGTT ; prohormone convertase; proinsulin; proinsulin to insulin ratio PI:I ;

   Abstract : Childhood obesity has surged globally. Elevated levels of free fatty acids contribute to hyperinsulinemia, hyperproinsulinemia, and hyperglucagonemia connected with both obesity and type 2 diabetes mellitus (T2DM). Metformin has beneficial effects on islets by influencing metabolism and reducing stress-induced cell death. READ MORE