Search for dissertations about: "hyperinsulinemia"

Showing result 16 - 20 of 46 swedish dissertations containing the word hyperinsulinemia.

  2. 16. Effects of insulin on the decidualization of human endometrial stromal cells : in vitro studies

    Author : Ivika Jakson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hyperinsulinemia is a known characteristic of obesity and polycystic ovary syndrome, two common clinical conditions associated with reproductive problems. However, the underlying mechanisms to reduced fertility are not fully elucidated, and the role of insulin in reproduction needs further investigation. READ MORE

  4. 17. Studies on glucagon secretion in patients with type 1 diabetes : clinical and experimental studies

    Author : Per Oskarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : C-peptide; CSII; CIPII; gluacon; insulin infusion test; severe hypoglycaemia; type 1 diabetes;

    Abstract : Hypoglycaernia is the main limiting factor reaching normo-glycaemia in type I diabetic patients. The risk of hypoglycaemia increases usually with improvements in metabolic control. The annual prevalence of severe episodes of hypoglycaemia in intensively treated patients is reported to be in the range 20-80%. READ MORE

  5. 18. Studies of the adipose tissue in insulin resistance with microdialysis

    Author : Madelene Sandqvist; Göteborgs universitet; []
    Keywords : ;

    Abstract : Type 2 diabetes is characterized by a combination of insulin resistance and an impaired insulin secretion. Theprevalence of the disease has taken epidemic proportions, and it is therefore of great concern to characterize itspathophysiology, as well as to identify individuals with increased risk for the disease, enabling to take measuresfor prevention and cure. READ MORE

  6. 19. Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease : Clinical Epidemiological Studies with up to 27 Years of Follow-Up

    Author : Björn Zethelius; Björn Fagerberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; diabetes; coronary heart disease; insulin; proinsulin; prognosis; mortality; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Geriatrics; geriatrik;

    Abstract : Defects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules. READ MORE

  7. 20. Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity

    Author : Marie Björnholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucose transport; insulin signal transduction; skeletal muscle; adipose tissue; type 2 diabetes mellitus; obesity; very low calorie diet.;

    Abstract : Studies of animal models of type 2 diabetes mellitus implicate that impaired insulin signal transduction to glucose transport accounts for whole body insulin resistance in skeletal muscle and adipose tissue. The overall aim of the present thesis was to determine insulin signal transduction to glucose transport in human skeletal muscle and adipose tissue from type 2 diabetic patients and obese insulin resistant subjects. READ MORE