Search for dissertations about: "hyperinsulinemia"

Showing result 6 - 10 of 46 swedish dissertations containing the word hyperinsulinemia.

  2. 6. Effects of prenatal IL-6 exposure and hyperinsulinemia on neuroendocrine regulation

    Author : Anne-Maj Samuelsson; Göteborgs universitet; []
    Keywords : interleukin-6; intrauterine exposure; HPA-axis; RAS; hippocampus; spatial learning; hypertension; insulin signaling; cardiac hypertrophy;

    Abstract : Prenatal exposure to infection is associated with several neuroendocrine disorders. We therefore wanted to elucidate if cytokines, generated in response to maternal infection, play a key mechanistic role in this associations. READ MORE

  4. 7. Effects of acute metabolic interventions on hemodynamics, endothelial function and forearm glucose uptake

    Author : Andreas Fugmann; Uppsala universitet; []
    Keywords : Medical sciences; Insulin; glucose; lipids; bloodflow; endothelium; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Hyperinsulinemia is known to augment endothelium-dependent.vasodilation (EDV). If physiological levels of insulin lead to peripheral, vasodilation and if this vasodilation is an independent determinant of skeletal muscle glucose uptake is however under debate. READ MORE

  5. 8. Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP

    Author : Ulrika Krus; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; pyruvate dehydrogenase kinase; beta-cells; pyruvate carboxylase; diabetology; Endokrinologi; sekretion; diabetologi; diabetes;

    Abstract : Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. READ MORE

  6. 9. Islet amyloid polypeptide : Perspectives on the storage and plasma concentration of islet amyloid polypeptide (IAPP) in rodent models of obesity and non-insulin-dependent diabetes mellitus and aspects of amyloidogenesis andelimination of IAPP

    Author : Arnold Leckström; Sture Falkmer; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The present study was aimed to investigate plasma concentrations and pancreatic storage of IAPP in relation to that of insulin in four different animal models with hyperglycemia, hyperinsulinemia, obesity and/or NIDDM. The NMRI mice fed a high-fat diet for six months, the Psammomys on high-energy (HE) diet and the genetically obese (ob/ob) mice studied for one year all revealed significantly elevated plasma IAPP concentrations, while the IAPP levels were unchanged in the spontaneously diabetic GK rats during a glucose tolerance test. READ MORE

  7. 10. Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function

    Author : Marie Guldstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Obesity; weight reduction; b ariatric surgery; insulin; glucagon; type 2 diabetes; insulin sensitivity; HPA axis; autonomic nervous system ANS ; cognitive functions; proinsulin; GIP; GLP-1; IGFBP- 1; diazoxide;

    Abstract : Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. READ MORE