Search for dissertations about: "hyperlipidemia and hyperglycemia"

Showing result 1 - 5 of 9 swedish dissertations containing the words hyperlipidemia and hyperglycemia.

  2. 1. Cardiovascular morbidity and metabolic signature in patients with rheumatoid arthritis

    Author : Mitra Nadali; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular mortality; Rheumatoid arthritis; metabolic signature;

    Abstract : Background and objectives: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with excess risk for cardiovascular morbidity and mortality. The treatment of RA by anti-inflammatory drugs has dramatically been improved over the resent decades. READ MORE

  4. 2. Adipose tissue as an active organ : blood flow regulation and tissue-specific glucocorticoid metabolism

    Author : Jonas Andersson; Tommy Olsson; Stefan Söderberg; Sverker Jern; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11β-hydroxysteroid dehydrogenase type 1; adipose tissue; autonomic nervous system; blood flow; cortisol; nitric oxide; weight loss.; medicin; Medicine;

    Abstract : Background: Despite advances in the treatment of atherosclerosis, cardiovascular disease is the leading cause of death worldwide. With the population getting older and more obese, the burden of cardiovascular disease may further increase. READ MORE

  5. 3. Copeptin in cardiovascular disease and dysglycemia

    Author : María Isabel Smáradóttir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: The impaired prognosis in patients with cardiovascular disease (CVD) and dysglycemia is not fully explained by traditional risk markers, among them hyperglycemia and hyperlipidemia. Understanding the developmental mechanism of CVD and identifying potential biomarkers are important parts in attempts to reduce cardiovascular mortality and morbidity in people with and without dysglyemia. READ MORE

  6. 4. The impact of glucotoxicity on pancreatic β-cell function

    Author : Sarheed Jabar Muhammed; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Abstract : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. READ MORE

  7. 5. Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression

    Author : Hamedeh Ghanaat-pour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hyperglycemia, deficient insulin secretion, and insulin resistance are the characteristic pathogenetic features of type 2 diabetes (T2D), hallmarked by functional and survival defects of the insulin-producing islet beta-cell. The primary pathogenesis of T2D probably involves both genetic and environmental forces, and hyperglycemia and very commonly hyperlipidemia might further aggravate beta-cell dysfunction. READ MORE