Search for dissertations about: "hypermethylation"
Showing result 1 - 5 of 52 swedish dissertations containing the word hypermethylation.
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1. DNA methylation and gene expression patterns in adrenal medullary tumors
Abstract : Pheochromocytomas and abdominal paragangliomas are neuroendocrine tumors of the autonomous nervous system, arising in adrenal medulla and sympathetic ganglia throughout the abdomen. These tumors originate from catecholamine-producing chromaffin cells. Neuroblastomas are common childhood tumors in the adrenal medulla and abdominal ganglia. READ MORE
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2. Genomic DNA methylation in health and disease
Abstract : Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases and cancer. READ MORE
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3. Genome-wide epigenetic profiling of B cell leukemia and lymphoma
Abstract : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. READ MORE
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4. Molecular aspects of tumor development and treatment for small intestinal neuroendocrine tumors
Abstract : Small intestinal neuroendocrine tumors (SI-NETs) may cause symptoms due to excess secretion of hormones and peptides. The molecular mechanisms behind development of SINETs are not well understood. Copy number alterations, especially loss of chromosome 18q, have been reported and recently p27 mutations were implicated in SI-NET tumorigenesis. READ MORE
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5. Tumors of the adrenal glands : genetic and diagnostic aspects
Abstract : Adrenal tumors have varying clinical presentation, malignancy rates and patient morbidity. Adrenal cortical carcinomas (ACCs) are malignant tumors originating from the adrenal cortex. READ MORE