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Showing result 1 - 5 of 154 swedish dissertations matching the above criteria.

2. 1. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

   Author : Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

   Abstract : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. READ MORE

4. 2. Metabolic function in adipocytes - focusing on hypertrophy and caveolae

   Author : Björn Hansson; Glukostransport och proteintrafficking; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocyte; hypertrophy; caveolae; adipose tissue; insulin resistance; EHD2; cytoskeleton; cavin 2;

   Abstract : .... READ MORE

5. 3. Signaling factors related to atrophy and hypertrophy in denervated skeletal muscle

   Author : Ann-Kristin Fjällström; Sven Tågerud; Jan Henriksson; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atrophy; Hypertrophy; Skeletal muscle; Denervation; Protein synthesis; Protein degradation; Biomedical Sciences; Biomedicinsk vetenskap;

   Abstract : The human body consists of about 40 % skeletal muscles which control the body’s movement, ability to stand up, force generation, locomotion, heat production and are also the body’s protein reservoir. Muscle mass is controlled by the relationship between protein synthesis and protein degradation. READ MORE

6. 4. Factors Contributing to Detrusor Overactivity - Obstruction, Hypertrophy and Afferent Nerve Stimulation

   Author : Annette Schröder; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacological sciences; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; knockout; mice; estrogen receptor; EP1 receptor; prostaglandin; rat; endothelin; detrusor overactivity; rabbit; smooth muscle; bladder outlet obstruction; hypertrophy; pharmacognosy;

   Abstract : The consequences of bladder outlet obstruction (BOO) with respect to detrusor hypertrophy, structural and functional changes, and obstruction-induced detrusor overactivity were investigated in vivo and in vitro utilizing various animal models. Possible pathophysiological pathways and therapeutic approaches were tested by drug treatment and the use of knockout models. READ MORE

7. 5. Function of contractile and cytoskeletal proteins in smooth muscle: Effects of hypertrophy and age and desmin removal in a transgenic animal

   Author : Rolf Sjuve; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transgenic mouse; desmin; embryonic myosin; isoforms; myosin heavy chain; age; smooth muscle; hypertrophy; Physiology; Fysiologi;

   Abstract : In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. READ MORE