Search for dissertations about: "hypothyroidism"

Showing result 11 - 15 of 46 swedish dissertations containing the word hypothyroidism.

  2. 11. Hypothyroidism caused by a mutant thyroid hormone receptor alpha1 : consequences for development and physiology

    Author : Maria Sjögren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lack of sufficient thyroid hormone during pregnancy and early postnatal development results in profound mental retardation and motor deficits whereas altered thyroid status in the adult is associated with disturbed metabolic homeostasis and impaired cardiac function. Thyroid hormone mediates its effects through the distinct thyroid hormone receptors (TR) TRalpha1 and TRbeta1-2, which are ligand-modulated transcription factors that regulate gene expression both in the presence and absence of hormone. READ MORE

  4. 12. Melatonin secretion and excretion : a clinical study focusing on factors and disease states which might influence melatonin

    Author : Johan Wikner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Melatonin; ethanol; Wernicke-Korsakoff syndrome; calcium; calcium channel blocker; verapamil; 6-sulphatoxy-melatonin; Obstructive Sleep Apnea Syndrome; Continuos Positive Airway Pressure; Fibromyalgic syndrome; TSH; somatostatin; octreotide; GH; Hypothyroidism;

    Abstract : The overall aim of this thesis was to find out whether other factors than the the light-dark changes influence the function of the pineal gland. Since melatonin (MT) itself, or its precursor serotonin, are of importance for sleep, mood, and pain perception, disease states - or situations in which these functions are disturbed - should be of interest to investigate in this context. READ MORE

  5. 13. Membrane transport of triiodothyronine : With particular reference to erythrocytes in health and disease

    Author : Ann-Charlotte Holm; Nils Nordén; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Cellular T3 uptake was studied in three human cell systems, i.e. cultured lymphocytes, erythrocytes and erythrocyte membrane vesicles. READ MORE

  6. 14. Down syndrome : Growth and endocrine impact

    Author : Åsa Myrelid; Jan Gustafsson; Göran Annerén; Ann-Christine Lindgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Down syndrome; growth; growth charts; body proportions; growth hormone; thyroid function; metabolism; body composition; cognition; motor development; Downs syndrom; tillväxt; tillväxtkurvor; kroppsproportioner; tillväxthormon; sköldkörtelfunktion; metabolism; kroppssammansättning; kognitiv förmåga; motorisk utveckling; Paediatric medicine; Pediatrisk medicin; pediatrik; Pediatrics;

    Abstract : Down syndrome (DS) is associated with psychomotor retardation, short stature and endocrine dysfunction. Statural growth is a well-known indicator of health. The growth in DS differs markedly from that of other children and there is a 20 cm reduction of final height as compared to target height. READ MORE

  7. 15. Description and prediction of clinical radiosensitivity : emphasis on normal tissue reactions

    Author : Roger Tell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Radiotherapy; radiosensitivity; normal tissue; thyroid; cell cycle; lung injury;

    Abstract : There is a range in the severity of normal tissue reactions observed when cancer patients receive radiotherapy (RT). The limits of dosage in RT have empirically been set by doses that have caused severe reactions in the most sensitive patients. The understanding of factors governing variations of radiosensitivity is therefore very important in RT. READ MORE