Search for dissertations about: "hypoxia and brain"

Showing result 1 - 5 of 84 swedish dissertations containing the words hypoxia and brain.

2. 1. Perinatal brain injury - markers and mediators. Non-protein-bound iron and pro-inflammatory cytokines in newborn infants and neonatal pigs

   Author : Karin Sävman; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asphyxia; hypoxia; posthemorrhagic ventricular dilatation; preterm; newborn; perinatal; brain; cerebrospinal fluid; cytokines; IL-1ß; IL-6; IL-8; TNF-a; non-protein-bound-iron;

   Abstract : Two groups of newborn infants have an increased risk for perinatal brain injury; preterm infants and term infants subjected to birth asphyxia. Experimental studies indicate that hypoxic-ischemic insults in the perinatal period initiate a secondary neurotoxic cascade including formation of toxic reactive oxygen species as well as an inflammatory response with elevated levels of potentially neurotoxic cytokines. READ MORE

4. 2. Diving and the brain

   Author : Anders Rosén; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomarkers; brain; central nervous system; decompression sickness; dive research; diving; neuronal damage; saturation diving; tau protein; venous gas embolism; neurofilament light; glial fibrillary acid protein; tau; VGE;

   Abstract : Abstract Introduction There are reports that long-term diving is associated with cognitive impairments. This raises the question if diving itself is harmful to the brain in the absence of decompression sickness or hypoxia. READ MORE

5. 3. Stromal and tumor cell responses to hypoxia and treatment within the glioma microenvironment

   Author : Vasiliki Pantazopoulou; Avdelningen för translationell cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; glioblastoma; tumor microenvironment; reactive astrocytes; hypoxia; CD44; p75NTR;

   Abstract : Glioblastoma is the most aggressive primary brain tumor in adults. Despite treatment, tumors invariably recur, and the recurring tumor is resistant to therapies. New approaches are needed for the successful treatment of glioblastoma patients.Tumors are not simply a compilation of molecularly and phenotypically identical neoplastic cells. READ MORE

6. 4. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity

   Author : Camilla Wallin; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glutathione; excitotoxicity; hypoxia-ischemia; brain; rat; anoxia-aglycemia; g-glutamyl transpeptidase; glutamate; NMDA; oxidative stress; mitochondria; amino acids;

   Abstract : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. READ MORE

7. 5. Developing brain and systemic inflammation: a "Toll-like" link with consequences

   Author : Amin Mottahedin; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; developing brain; neonatal brain injury; hypoxia-ischemia; inflammation; infection; Toll-like receptor; choroid plexus; neuroimmunology; Mitochondria;

   Abstract : The developing brain is vulnerable to external insults, and perinatal brain injury (PBI) is a major cause of life-long neurological syndromes such as cerebral palsy. Currently, no pharmaceutical intervention is available. Hypoxia/ischemia (HI), infections and inflammation are implicated in the pathogenesis of PBI. READ MORE