Search for dissertations about: "hypoxia radiation"

Showing result 1 - 5 of 21 swedish dissertations containing the words hypoxia radiation.

  2. 1. Accurate description of heterogeneous tumors for biologically optimized radiation therapy

    Author : Johan Nilsson; Bengt Lind; Anders Brahme; Margareta Edgren; Søren Bentzen; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heterogeneous tumors; radiation therapy; biological optimization; tumor hypoxia; effective radiation sensitivity; effective radiation resistance; Radiation biology; Strålningsbiologi;

    Abstract : In this thesis, a model of tissue oxygenation is presented, that takes into account the heterogeneous nature of tumor vasculature. Even though the model is rather simple, the resulting oxygen distributions agree very well with clinically observed oxygen distributions for most tumors and healthy normal tissues. READ MORE

  4. 2. Theoretical modelling of tumour oxygenation and influences on treatment outcome

    Author : Iuliana Toma-Dasu; Mikael Karlsson; Svensson Hans; J F Fowler; Borivoj Vojnovic; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Computer simulation; Electrode; Polarographic measurements; Tumour oxygenation; Hypoxia; Strålningsvetenskap; Radiation biology; Strålningsbiologi; radiofysik; radiation physics;

    Abstract : One of the main problems in curing cancer resides in the different microenvironment existing in tumours compared to the normal tissues. The mechanisms of failure are different for radiotherapy and chemotherapy, but they all relate to the poor blood supply known to exist in tumours. READ MORE

  5. 3. Time, dose and fractionation: accounting for hypoxia in the search for optimal radiotherapy treatment parameters

    Author : Emely Kjellsson Lindblom; Iuliana Toma-Dasu; Peter Wersäll; David J Carlson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hypoxia; radiobiological modelling; radiotherapy; functional imaging; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : The search for the optimal choice of treatment time, dose and fractionation regimen is one of the major challenges in radiation therapy. Several aspects of the radiation response of tumours and normal tissues give different indications of how the parameters defining a fractionation schedule should be altered relative to each other which often results in contradictory conclusions. READ MORE

  6. 4. Searching for the optimal radiotherapy treatment time, dose and fractionation - the role of hypoxia and reoxygenation : A modelling study

    Author : Emely Lindblom; Iuliana Toma-Dasu; Ingmar Lax; Ludvig Paul Muren; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hypoxia; Reoxygenation; SBRT; Fractionation; Medical Radiation Physics; medicinsk strålningsfysik;

    Abstract : The search for the optimal choice of treatment time, dose and fractionation regimen is one of the major challenges in radiation therapy. Several aspects of the radiation response of tumours and normal tissues give different indications of how the parameters defining a fractionation schedule should be altered relative to each other which often results in contradictory conclusions. READ MORE

  7. 5. Hypoxia inducible factor-1α in renal cell carcinoma

    Author : Anders Lidgren; Börje Ljungberg; Torgny Rasmuson; Kjell Grankvist; Anders Bergh; Per-Uno Malmström; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal cell carcinoma; hypoxia; RT-PCR; angiogenesis; western blot; tissue microarray; protein; mRNA; HIF-1 alpha; GLUT-1; survival; Urology and andrology; Urologi och andrologi;

    Abstract : Hypoxia Inducible Factor-1α in Renal Cell Carcinoma Departments of Surgical and Perioperative Sciences, Urology and Andrology; Radiation Sciences, Oncology; Medical Biosciences, Pathology; and Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all human cancers. A distinguished feature of RCC is vascularisation and among the three dominating RCC types conventional RCC (cRCC) generally is more vascularised than papillary RCC (pRCC) and chromophobe RCC (chRCC). READ MORE