Search for dissertations about: "hypoxia"

Showing result 6 - 10 of 443 swedish dissertations containing the word hypoxia.

  2. 6. Hypoxia and differentiation in human neuroblastoma cells

    Author : Helén Nilsson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ; teratology; cytogenetik; Development biology; cytogenetics; Genetik; Genetics; Medicin människa och djur ; HIF; Medicine human and vertebrates ; MYCN; Hypoxia; differentiation; Neuroblastoma;

    Abstract : The childhood tumour neuroblastoma is derived from immature cells of the sympathetic nervous system, which have become arrested at different maturation stages. Neuroblastoma is a malignancy with a high degree of heterogeneity, and there is a correlation between a poor differentiation status and a more aggressive phenotype. READ MORE

  4. 7. Hypoxia-inducible factors (HIFs) and biological responses, in hypoxia, inflammation and embryonic vascular development

    Author : Maria Hägg; Göteborgs universitet; []
    Keywords : Embryonic stem cell; embryoid body; HIF-1a; hypoxia; VEGF; angiogenesis; vasculogenesis; peritoneal dialysis;

    Abstract : ABSTRACT Low oxygen tension (hypoxia) is a major inducer of neovascularisation and evidence emerging has indicated that oxygen tension and hypoxia-inducible factors (HIFs), a family of oxygen-regulated heterodimeric transcription factors, may play important roles in vascular and hematopoietic development. This thesis has focused on studying molecular and cellular mechanisms, by which cells and organisms sense changes in oxygen tension, and how this signal is transduced by HIFs into downstream signalling. READ MORE

  5. 8. The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis

    Author : Annika Asplund; Göteborgs universitet; []
    Keywords : atherosclerosis; proteoglycans; glycosaminoglycans; macrophages; hypoxia; hypoxia-inducible transcription factor; LDL binding; cell motility;

    Abstract : A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). READ MORE

  6. 9. Glucose- and hypoxia-regulated insulin gene expression

    Author : Linda Tillmar; Jens Höiriis Nielsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islet; beta-cell; insulin; mRNA stability; PTB; glucose; hypoxia; mTOR; p70s6k; ceramide; redox; ROS; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. READ MORE

  7. 10. THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate

    Author : Matilda Rehn; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic Stem Cells; Stem Cell Niche; Hypoxia; Hypoxia-Inducible Factor; Vegfa.;

    Abstract : Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. READ MORE