Search for dissertations about: "iPLA 2"

Found 2 swedish dissertations containing the words iPLA 2.

  2. 1. Biosynthesis of leukotriene B4 in hematological malignancies

    Author : Gudmundur Runarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : LTB 4; 5-LO; cPLA 2; iPLA 2; AML; B-ALL; B-CLL;

    Abstract : Leukotrienes (LT) are biologically active metabolites of the fatty acid arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA 2), this fatty acid can be converted to leukotrienes, lipoxins, prostaglandins or thromboxane. The conversion of AA to LTA 4 is catalyzed by five-lipoxygenase (5-LO). READ MORE

  4. 2. The effect of intra-abdominal local anaesthetics following major gynaecological surgery. Clinical and experimental studies

    Author : Jane M. Hayden; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Local anaesthetics; postoperative pain; hysterectomy; inflammation; ropivacaine toxicity; ovarian cancer; recovery; ovarian cancer cells;

    Abstract : Background: Local anaesthetics (LA), in addition to inhibition of pain signalling, also have anti-inflammatory properties. In vitro studies have demonstrated anti-proliferative and cytotoxic effect of LAs on cancer cells when administered in therapeutic concentrations. READ MORE