Search for dissertations about: "iPSC"

Showing result 11 - 15 of 26 swedish dissertations containing the word iPSC.

  2. 11. Inflammation and Stem Cell Therapy for Stroke

    Author : Ruimin Ge; Lund Neurologi; []
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    Abstract : Ischemic stroke is a leading cause of death and disability worldwide. Currently, there is no treatment that can promote recovery in the chronic phase. It has been shown that neurogenesis occurs in ischemic striatum in rodents and probably also in humans. READ MORE

  4. 12. Modelling and genetic correction of liver genetic diseases

    Author : Mihaela Zabulica; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : The urea cycle is a set of biochemical reactions that converts highly toxic ammonia into urea for excretion. Deficiencies in any of the genes of the cycle can be life-threatening, with liver transplantation currently being the only definitive treatment. READ MORE

  5. 13. Brain development in a dish

    Author : Robin Johan Pronk; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole new fields of study and unprecedented possibilities of generating human cells in vitro. READ MORE

  6. 14. Cellular models of human brain disorders from skin to brain

    Author : Mansoureh Shahsavani; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : Studying human brain development and disorders is very challenging. In the absence of comparable model organisms, human-related models, and limitations to obtain live cells from the human brain, induced Pluripotent Stem Cell (iPSC) technology, in particular, provided a unique tool to study the disease mechanisms and investigate potential treatments. READ MORE

  7. 15. Modeling human germ cell development with pluripotent stem cells and characterizing the putative oogonial stem cells

    Author : Sarita Panula; Karolinska Institutet; Karolinska Institutet; []
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    Abstract : The current understanding of human germ cell development is limited and is at most parts extrapolated from studies of mice or other model organisms. Particularly, the specification events of human germ cell lineage are largely unknown, which is at least in part due to inaccessibility of early stages of human development. READ MORE