Search for dissertations about: "idiotype"

Showing result 1 - 5 of 10 swedish dissertations containing the word idiotype.

  2. 1. Functional mapping and in vivo metabolism of the monoclonal antibody TS1 and its single-chain fragment : Its interaction with the antigen and the anti-idiotype

    Author : Patrik Holm; Birgitta Sundström; Lars Gedda; Karlstads universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single-chain antibody; functional mapping; site-directed mutagenesis; immune complex; metabolism; Molecular biology; Molekylärbiologi; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

    Abstract : Antibodies are proteins capable of specific interactions to a wide range of molecules. These interactions are facilitated by the complementary determining regions (CDR).Carcinomas are the most common of human cancers and they release significant amount of cytokeratins (CK) in the necrotic areas of the tumors. READ MORE

  4. 2. Natural and induced idiotype immunity in patients with multiple myeloma

    Author : Lotta Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Myeloma; idiotype; vaccination; GM-CSF; IL-12; clonal B cells; T cell epitopes; signal transduction molecules; activation markers;

    Abstract : There is a great need for development of new treatment alternatives for patients with multiple myeloma (MM). The idiotype (Id) immunoglobulin (Ig) expressed by the myeloma B cell clone might be regarded as a tumor specific antigen and as such a target for immunotherapy. READ MORE

  5. 3. Single-chain antibody construction and functional mapping of the monoclonal antibody TS1 : Its interaction with the antigen and the anti-idiotype

    Author : Patrik Holm; Birgitta Sundström; Per-Åke Nygren; Karlstads universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemistry; Kemi; Chemistry; Kemi; Biomedicin; Biomedical Laboratory Science;

    Abstract : The aims of this study are to synthesize and produce a single-chain antibody (scFv) of the anti-cytokeratin 8 monoclonal IgG antibody TS1 and to functionally map amino acid residues important for the interaction with its antigen and the anti-idiotypic antibody TS1. The TS1 antibody has been shown to be effective in binding cytokeratin 8 (CK8) expressed in tumors in vivo and is proposed to be useful in immunotargeting and/or immunotherapy. READ MORE

  6. 4. Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients

    Author : Amir Osman Abdalla; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Idiotype; vaccination; multiple myeloma; T cell response;

    Abstract : In spite of the promising results shown by new anti-myeloma agents, multiple myeloma (MM) remains incurable and additional therapy to overcome the inevitable disease recurrence is greatly needed. Immunotherapy is currently under evaluation as a novel alternative or complementary therapy in many cancer types. READ MORE

  7. 5. Invasive Haemophilus influenzae Infection and Breastfeeding : Aspects of epidemiology and immunology

    Author : Sven-Arne Silfverdal; Heikki Peltola; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Invasive Haemophilus influenzae (Hi) infection is still an important cause of morbidity and mortality in the world. Vaccination against Haemophilus influenzae type b (Hib) has been implemented in many industrial countries during the 1990s with a dramatic decrease in mortality and morbidity due to Hib. READ MORE