Search for dissertations about: "igf-i"

Showing result 21 - 25 of 161 swedish dissertations containing the word igf-i.

  2. 21. Growth hormone responsiveness in children : results from Swedish multicenter clinical trials of growth hormone treatment

    Author : Elena Lundberg; Berit Kriström; Kerstin Albertsson-Wikland; Roland Pfäffle; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gain in height; puberty; IGHD; non-GHD; IGF-I; bioavailability;

    Abstract : The general aims of the thesis were to study GH responsiveness by estimation of pharmacokinetics and bioavailability of injected recombinant human GH (rhGH), of growth response as gain in heightSDS during childhood and puberty, and IGF-I response as change in circulating IGF-ISDS and IGFBP3SDS. Methods Short children were recruited during 1988–1999 into two national randomized multicentre clinical trials on growth until adult height. READ MORE

  4. 22. IGF-I in growth hormone deficiency and in type 1 diabetes

    Author : Bertil Ekman; Jens Sandahl Christiansen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Both GH-deficiency and type 1 diabetes are associated with low IGF-I levels. The aim with our studies was to develop a dose titration model to obtain physiological IGF-I levels in growth hormone deficiency and to evaluate the relationship between glycaemic control and IGF-I in diabetes. READ MORE

  5. 23. Cardiovascular effects of growth hormone, IGF-I and growth hormone secretagogues

    Author : Åsa Tivesten; Göteborgs universitet; []
    Keywords : cardiovascular system; growth hormone; insulin-like growth factor-I; growth hormone secretagogues; echocardiography.;

    Abstract : Growth hormone (GH) may exert direct growth-promoting and metabolic actions on target tissues, but most of its effects are mediated by circulating (endocrine) or local (auto-/paracrine) insulin-like growth factor-I (IGF-I). The GH/IGF-I system has an important role during cardiac development and for maintaining the structure and function of the heart. READ MORE

  6. 24. Insulin resistance and IGF-I sensitivity in vascular cells - impact of hybrid receptors : With special regard to diabetes

    Author : Git Johansson; Hans Arnqvist; Pierre De Meyts; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Diabetic complications largely affect the circulation and are associated with resistance to insulin and altered levels of insulin-like growth factor-I (IGF-I). Insulin resistance and altered IGF-I levels are also associated with vascular disease. READ MORE

  7. 25. Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling

    Author : Ileana Ruxandra Botusan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology and pathology to be able to design therapies for several diseases where angiogenesis is dysregulated (either excessive or diminished). READ MORE