Search for dissertations about: "igm"

Showing result 1 - 5 of 192 swedish dissertations containing the word igm.

2. 1. The Role of IgM and Complement in Antibody Responses

   Author : Christian Rutemark; Birgitta Heyman; Claus Nielsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

   Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE

4. 2. Feedback Enhancement of Immune Responses by IgE, IgM, and IgG3 Antibodies

   Author : Zhoujie Ding; Birgitta Heyman; Eva Severinson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgE; IgM; IgG3; antibody responses; T-cell responses; antigen transportation; antigen presentation; complement; complement receptors 1 and 2; Immunologi; Immunology;

   Abstract : Antibodies can enhance or suppress the immune responses against their specific antigens. This phenomenon is known as antibody-mediated feedback regulation. We have studied the mechanisms underlying IgE-, IgM-, and IgG3-mediated enhancement of immune responses in mouse models using intravenous immunization. READ MORE

5. 3. IgG3 Complements IgM in the Complement-Mediated Regulation of Immune Responses

   Author : Lu Zhang; Birgitta Heyman; Jenny Hallgren; Frida Henningsson; Kristina Lejon; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgG3; IgM; marginal zone B cells; follicular dendritic cells; complement receptors 1 and 2; C1q; C3; antigen transport; Immunologi; Immunology;

   Abstract : An intact complement system is essential for the initiation of a normal antibody response. Antibodies can regulate their own production against the antigens that they are specific for. Both IgG3 and IgM are able to enhance the antibody response via complement. READ MORE

6. 4. Diagnostic and prognostic value of proteinuria in chronic renal diseases

   Author : Omran Bakoush; Njurmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; Hypertension.; Glomerulonephritis; IgM; Albuminuria; Diabetic Nephropathy; nephrology; Urologi; nefrologi;

   Abstract : To the extent that increased urinary protein excretion is an indicator of alterations of the glomerular capillary wall (GCW) and appearance of tubulointerstitial damage, proteinuria can be a good marker of the overall severity of the glomerular and tubulointerstitial damage, and therefore, the prognosis of glomerular diseases. Studies I, II, and III show that it is the type of proteinuria, rather than the degree of albuminuria, that predicts the progression in renal, proteinuric diseases. READ MORE

7. 5. Feedback Enhancement of Antibody Responses via Complement and Fc Receptors

   Author : Jörgen Dahlström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; complement; IgG; IgM; IgE; Fc-gamma-RI; Fc-gamma-RII; Fc-gamma-RIII; CR1; CR2; CD21; CD35; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Abstract : IgG, IgM and IgE in complex with antigen have the capacity to regulate specific immune responses. In this investigation, the role of Fc receptors for IgG (FcγRI, FcγRII and FcγRIII) and complement receptors 1 and 2 (CR1/2) for antibody-mediated enhancement of antibody responses are investigated. READ MORE