Search for dissertations about: "ihc study"

Showing result 1 - 5 of 84 swedish dissertations containing the words ihc study.

  2. 1. Genotype-phenotype studies in brain tumors

    Author : Soma Ghasimi; Ulrika Andersson; Beatrice Melin; Roger Henriksson; Clemens Dirven; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; Meningioma; SNP; IHC; FISH; LRIG2; EGF; EGFR; ERBB2; ER; CDKN2A B; IDH1; onkologi; Oncology;

    Abstract : Meningioma and glioma are the most common primary brain tumors, but their etiologies are largely unknown. Although meningioma is usually benign, their intracranial location can lead to lethal consequences, and despite progress in surgery, radiotherapy, and chemotherapy the prognosis for patients with glioma remains poor. READ MORE

  4. 2. Prognostic and Predictive Factors in Bladder Cancer

    Author : Tammer Hemdan; Per-Uno Malmström; Ulrika Segersten; Peter Boström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bladder cancer; BCG; cisplatin; STMN1; emmprin; survivin; CCTα; biomarker; immunohistochemistry; IHC; tissue microarray; TMA;

    Abstract : Bladder cancer is a potentially curable malignancy; however in regards to the state of current therapy regimens, a plateau has been reached in both the non-muscle and muscle invasive types. To obtain effective treatment, and consequently a decreased mortality, it has become imperative to test and understand aspects affecting therapy response. READ MORE

  5. 3. Through the magnifying glass - The big small world of marine meiofauna : Morphology, species and evolution in Nemertodermatida

    Author : Inga Meyer-Wachsmuth; Ulf Jondelius; Mark E Sidall; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nemertodermatida; Acoelomorpha; morphology; CLSM; Phalloidin; musculature; DNA; cryptic species; species delimitation; dispersal; taxonomy; phylogenetics; IHC; nervous system; Systematic Zoology; zoologisk systematik och evolutionsforskning;

    Abstract : Nemertodermatida is a group of microscopic marine worm-like animals that live as part of the marine meiofauna in sandy or muddy sediments; one species lives commensally in a holothurian. These benthic worms were thought to disperse passively with ocean currents, resulting in little speciation and thus wide or even cosmopolitan distributions. READ MORE

  6. 4. Validation of antibodies for tissue based immunoassays

    Author : Sandra Andersson; Anna Asplund; Fredrik Pontén; Kenneth Wester; Mike Taussig; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibody validation; Conjugation; Estrogen receptor-beta; IHC; ISH; Lymphohematopoietic tissues; Proteomic; RNAseq; TMA; Transcriptomic; Patologi; Pathology;

    Abstract : In situ protein detection in human tissues using antibodies reveals the cellular protein localization, and affinity-based proteomic studies can help to discover proteins involved in the development of diseases. However, antibodies often suffer from cross-reactivity, and the lack of positive and negative tissue controls for uncharacterized proteins complicates the mapping of the proteome. READ MORE

  7. 5. Validation of antibodies for protein profiling : A study using immunohistochemistry on tissue microarrays

    Author : Linda Paavilainen; Fredrik Pontén; Ola Nilsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; Pathology; Patologi; Pathology; patologi;

    Abstract : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. READ MORE